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The efficacy of alum sitz baths followed by topical gall ointment in hemorrhoids—a single-arm clinical trial

Hemorrhoidal disease is one of the most common gastrointestinal ailments affecting life quality of the patients. Unani classical literature is replete with anti-hemorrhoidal drugs, but scientific evidence is lacking. Therefore, Safūf Zāj (powdered alum) and Marham-e-Māzū (gall ointment) having poten...

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Autores principales: Chaush, Salma, Husain, Nazim, Khalid, Mohd, Doni, Meenu, Khan, Mohd Qudrathullah, Hussain, Md Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819210/
http://dx.doi.org/10.1007/s13596-022-00634-6
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author Chaush, Salma
Husain, Nazim
Khalid, Mohd
Doni, Meenu
Khan, Mohd Qudrathullah
Hussain, Md Majid
author_facet Chaush, Salma
Husain, Nazim
Khalid, Mohd
Doni, Meenu
Khan, Mohd Qudrathullah
Hussain, Md Majid
author_sort Chaush, Salma
collection PubMed
description Hemorrhoidal disease is one of the most common gastrointestinal ailments affecting life quality of the patients. Unani classical literature is replete with anti-hemorrhoidal drugs, but scientific evidence is lacking. Therefore, Safūf Zāj (powdered alum) and Marham-e-Māzū (gall ointment) having potent anti-hemorrhoidal actions were selected to evaluate their efficacy in hemorrhoids. This clinical trial was conducted on 30 participants with hemorrhoids, aged > 18 years. All the participants received Safūf Zāj for sitz baths and Marham-e-Māzū to be applied twice daily for 2 weeks. Primary outcome measures were: change in pain intensity, anal itching, and defecate discomfort assessed on 100 mm VAS scale and per-rectal bleeding assessed on 4-point scale. Secondary outcome measures were: change in the size of the external hemorrhoidal mass assessed on 5-point scale, grade of internal hemorrhoid assessed by Goligher classification and quality of life (QoL) assessed on SF-12 questionnaire. The per-protocol analysis was done on 30 participants and statistically significant improvement was seen in primary and secondary outcome measures. Moreover, both the mental and psychological components of QoL were improved. The study inferred that therapeutic approach of Safūf Zāj and Marham-e-Mazu is safe and efficacious in hemorrhoids. Future studies with well-designed RCTs are highly recommended. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13596-022-00634-6.
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spelling pubmed-88192102022-02-07 The efficacy of alum sitz baths followed by topical gall ointment in hemorrhoids—a single-arm clinical trial Chaush, Salma Husain, Nazim Khalid, Mohd Doni, Meenu Khan, Mohd Qudrathullah Hussain, Md Majid ADV TRADIT MED (ADTM) Research Article Hemorrhoidal disease is one of the most common gastrointestinal ailments affecting life quality of the patients. Unani classical literature is replete with anti-hemorrhoidal drugs, but scientific evidence is lacking. Therefore, Safūf Zāj (powdered alum) and Marham-e-Māzū (gall ointment) having potent anti-hemorrhoidal actions were selected to evaluate their efficacy in hemorrhoids. This clinical trial was conducted on 30 participants with hemorrhoids, aged > 18 years. All the participants received Safūf Zāj for sitz baths and Marham-e-Māzū to be applied twice daily for 2 weeks. Primary outcome measures were: change in pain intensity, anal itching, and defecate discomfort assessed on 100 mm VAS scale and per-rectal bleeding assessed on 4-point scale. Secondary outcome measures were: change in the size of the external hemorrhoidal mass assessed on 5-point scale, grade of internal hemorrhoid assessed by Goligher classification and quality of life (QoL) assessed on SF-12 questionnaire. The per-protocol analysis was done on 30 participants and statistically significant improvement was seen in primary and secondary outcome measures. Moreover, both the mental and psychological components of QoL were improved. The study inferred that therapeutic approach of Safūf Zāj and Marham-e-Mazu is safe and efficacious in hemorrhoids. Future studies with well-designed RCTs are highly recommended. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13596-022-00634-6. Springer Nature Singapore 2022-02-07 2023 /pmc/articles/PMC8819210/ http://dx.doi.org/10.1007/s13596-022-00634-6 Text en © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Article
Chaush, Salma
Husain, Nazim
Khalid, Mohd
Doni, Meenu
Khan, Mohd Qudrathullah
Hussain, Md Majid
The efficacy of alum sitz baths followed by topical gall ointment in hemorrhoids—a single-arm clinical trial
title The efficacy of alum sitz baths followed by topical gall ointment in hemorrhoids—a single-arm clinical trial
title_full The efficacy of alum sitz baths followed by topical gall ointment in hemorrhoids—a single-arm clinical trial
title_fullStr The efficacy of alum sitz baths followed by topical gall ointment in hemorrhoids—a single-arm clinical trial
title_full_unstemmed The efficacy of alum sitz baths followed by topical gall ointment in hemorrhoids—a single-arm clinical trial
title_short The efficacy of alum sitz baths followed by topical gall ointment in hemorrhoids—a single-arm clinical trial
title_sort efficacy of alum sitz baths followed by topical gall ointment in hemorrhoids—a single-arm clinical trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819210/
http://dx.doi.org/10.1007/s13596-022-00634-6
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