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Association between depression and sleep apnoea: a Mendelian randomisation study

BACKGROUND: Studies have reported a close relationship between depression and sleep apnoea, yet it is unknown whether these are causally related. Thus, we aimed to determine whether depression is associated with the aetiology of sleep apnoea. METHODS: We used publicly available genetic summary data...

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Autores principales: Chen, Gui, Xie, Junyang, Liu, Weixing, Liang, Tianhao, Liao, Xiao, Liao, Wenjing, Song, Lijuan, Zhang, Xiaowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819249/
https://www.ncbi.nlm.nih.gov/pubmed/35141322
http://dx.doi.org/10.1183/23120541.00394-2021
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author Chen, Gui
Xie, Junyang
Liu, Weixing
Liang, Tianhao
Liao, Xiao
Liao, Wenjing
Song, Lijuan
Zhang, Xiaowen
author_facet Chen, Gui
Xie, Junyang
Liu, Weixing
Liang, Tianhao
Liao, Xiao
Liao, Wenjing
Song, Lijuan
Zhang, Xiaowen
author_sort Chen, Gui
collection PubMed
description BACKGROUND: Studies have reported a close relationship between depression and sleep apnoea, yet it is unknown whether these are causally related. Thus, we aimed to determine whether depression is associated with the aetiology of sleep apnoea. METHODS: We used publicly available genetic summary data from two large consortia: the Psychiatric Genomics Consortium, with data from 36 single-nucleotide polymorphisms (SNPs) closely associated with major depressive disorder (MDD), and the UK Biobank, including 456 736 patients with sleep apnoea and 766 964 controls. For Mendelian randomisation (MR) analysis, we used the inverse-variance weighted method, weighted median method, MR-Egger regression, MR pleiotropy residual sum and outlier test to retrieve summary data. Analyses were performed using the “TwoSampleMR” package in R. RESULTS: Out of the 36 SNPs associated with MDD, we found statistically significant evidence of a potential causal effect of MDD on the risk of sleep apnoea (OR 1.004, 95% CI 1.001–1.006; p=0.001). Similar results were obtained using the MR-Egger and weighted median methods. Additionally, we found no heterogeneity or pleiotropy. CONCLUSIONS: Our findings suggest that depression slightly increases the risk of sleep apnoea. Further investigation of the potential biological mechanisms is necessary.
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spelling pubmed-88192492022-02-08 Association between depression and sleep apnoea: a Mendelian randomisation study Chen, Gui Xie, Junyang Liu, Weixing Liang, Tianhao Liao, Xiao Liao, Wenjing Song, Lijuan Zhang, Xiaowen ERJ Open Res Original Research Article BACKGROUND: Studies have reported a close relationship between depression and sleep apnoea, yet it is unknown whether these are causally related. Thus, we aimed to determine whether depression is associated with the aetiology of sleep apnoea. METHODS: We used publicly available genetic summary data from two large consortia: the Psychiatric Genomics Consortium, with data from 36 single-nucleotide polymorphisms (SNPs) closely associated with major depressive disorder (MDD), and the UK Biobank, including 456 736 patients with sleep apnoea and 766 964 controls. For Mendelian randomisation (MR) analysis, we used the inverse-variance weighted method, weighted median method, MR-Egger regression, MR pleiotropy residual sum and outlier test to retrieve summary data. Analyses were performed using the “TwoSampleMR” package in R. RESULTS: Out of the 36 SNPs associated with MDD, we found statistically significant evidence of a potential causal effect of MDD on the risk of sleep apnoea (OR 1.004, 95% CI 1.001–1.006; p=0.001). Similar results were obtained using the MR-Egger and weighted median methods. Additionally, we found no heterogeneity or pleiotropy. CONCLUSIONS: Our findings suggest that depression slightly increases the risk of sleep apnoea. Further investigation of the potential biological mechanisms is necessary. European Respiratory Society 2021-02-07 /pmc/articles/PMC8819249/ /pubmed/35141322 http://dx.doi.org/10.1183/23120541.00394-2021 Text en Copyright ©The authors 2022 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Original Research Article
Chen, Gui
Xie, Junyang
Liu, Weixing
Liang, Tianhao
Liao, Xiao
Liao, Wenjing
Song, Lijuan
Zhang, Xiaowen
Association between depression and sleep apnoea: a Mendelian randomisation study
title Association between depression and sleep apnoea: a Mendelian randomisation study
title_full Association between depression and sleep apnoea: a Mendelian randomisation study
title_fullStr Association between depression and sleep apnoea: a Mendelian randomisation study
title_full_unstemmed Association between depression and sleep apnoea: a Mendelian randomisation study
title_short Association between depression and sleep apnoea: a Mendelian randomisation study
title_sort association between depression and sleep apnoea: a mendelian randomisation study
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819249/
https://www.ncbi.nlm.nih.gov/pubmed/35141322
http://dx.doi.org/10.1183/23120541.00394-2021
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