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Association between depression and sleep apnoea: a Mendelian randomisation study
BACKGROUND: Studies have reported a close relationship between depression and sleep apnoea, yet it is unknown whether these are causally related. Thus, we aimed to determine whether depression is associated with the aetiology of sleep apnoea. METHODS: We used publicly available genetic summary data...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819249/ https://www.ncbi.nlm.nih.gov/pubmed/35141322 http://dx.doi.org/10.1183/23120541.00394-2021 |
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author | Chen, Gui Xie, Junyang Liu, Weixing Liang, Tianhao Liao, Xiao Liao, Wenjing Song, Lijuan Zhang, Xiaowen |
author_facet | Chen, Gui Xie, Junyang Liu, Weixing Liang, Tianhao Liao, Xiao Liao, Wenjing Song, Lijuan Zhang, Xiaowen |
author_sort | Chen, Gui |
collection | PubMed |
description | BACKGROUND: Studies have reported a close relationship between depression and sleep apnoea, yet it is unknown whether these are causally related. Thus, we aimed to determine whether depression is associated with the aetiology of sleep apnoea. METHODS: We used publicly available genetic summary data from two large consortia: the Psychiatric Genomics Consortium, with data from 36 single-nucleotide polymorphisms (SNPs) closely associated with major depressive disorder (MDD), and the UK Biobank, including 456 736 patients with sleep apnoea and 766 964 controls. For Mendelian randomisation (MR) analysis, we used the inverse-variance weighted method, weighted median method, MR-Egger regression, MR pleiotropy residual sum and outlier test to retrieve summary data. Analyses were performed using the “TwoSampleMR” package in R. RESULTS: Out of the 36 SNPs associated with MDD, we found statistically significant evidence of a potential causal effect of MDD on the risk of sleep apnoea (OR 1.004, 95% CI 1.001–1.006; p=0.001). Similar results were obtained using the MR-Egger and weighted median methods. Additionally, we found no heterogeneity or pleiotropy. CONCLUSIONS: Our findings suggest that depression slightly increases the risk of sleep apnoea. Further investigation of the potential biological mechanisms is necessary. |
format | Online Article Text |
id | pubmed-8819249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-88192492022-02-08 Association between depression and sleep apnoea: a Mendelian randomisation study Chen, Gui Xie, Junyang Liu, Weixing Liang, Tianhao Liao, Xiao Liao, Wenjing Song, Lijuan Zhang, Xiaowen ERJ Open Res Original Research Article BACKGROUND: Studies have reported a close relationship between depression and sleep apnoea, yet it is unknown whether these are causally related. Thus, we aimed to determine whether depression is associated with the aetiology of sleep apnoea. METHODS: We used publicly available genetic summary data from two large consortia: the Psychiatric Genomics Consortium, with data from 36 single-nucleotide polymorphisms (SNPs) closely associated with major depressive disorder (MDD), and the UK Biobank, including 456 736 patients with sleep apnoea and 766 964 controls. For Mendelian randomisation (MR) analysis, we used the inverse-variance weighted method, weighted median method, MR-Egger regression, MR pleiotropy residual sum and outlier test to retrieve summary data. Analyses were performed using the “TwoSampleMR” package in R. RESULTS: Out of the 36 SNPs associated with MDD, we found statistically significant evidence of a potential causal effect of MDD on the risk of sleep apnoea (OR 1.004, 95% CI 1.001–1.006; p=0.001). Similar results were obtained using the MR-Egger and weighted median methods. Additionally, we found no heterogeneity or pleiotropy. CONCLUSIONS: Our findings suggest that depression slightly increases the risk of sleep apnoea. Further investigation of the potential biological mechanisms is necessary. European Respiratory Society 2021-02-07 /pmc/articles/PMC8819249/ /pubmed/35141322 http://dx.doi.org/10.1183/23120541.00394-2021 Text en Copyright ©The authors 2022 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org) |
spellingShingle | Original Research Article Chen, Gui Xie, Junyang Liu, Weixing Liang, Tianhao Liao, Xiao Liao, Wenjing Song, Lijuan Zhang, Xiaowen Association between depression and sleep apnoea: a Mendelian randomisation study |
title | Association between depression and sleep apnoea: a Mendelian randomisation study |
title_full | Association between depression and sleep apnoea: a Mendelian randomisation study |
title_fullStr | Association between depression and sleep apnoea: a Mendelian randomisation study |
title_full_unstemmed | Association between depression and sleep apnoea: a Mendelian randomisation study |
title_short | Association between depression and sleep apnoea: a Mendelian randomisation study |
title_sort | association between depression and sleep apnoea: a mendelian randomisation study |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819249/ https://www.ncbi.nlm.nih.gov/pubmed/35141322 http://dx.doi.org/10.1183/23120541.00394-2021 |
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