Cargando…

TAS‐116 (pimitespib), a heat shock protein 90 inhibitor, shows efficacy in preclinical models of adult T‐cell leukemia

Adult T‐cell leukemia/lymphoma (ATL) is a highly chemoresistant malignancy of peripheral T lymphocytes caused by human T‐cell leukemia virus type 1 infection, for which there is an urgent need for more effective therapeutic options. The molecular chaperone heat shock protein 90 (HSP90) plays a cruci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ikebe, Emi, Shimosaki, Shunsuke, Hasegawa, Hiroo, Iha, Hidekatsu, Tsukamoto, Yoshiyuki, Wang, Yu, Sasaki, Daisuke, Imaizumi, Yoshitaka, Miyazaki, Yasushi, Yanagihara, Katsunori, Hamaguchi, Isao, Morishita, Kazuhiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819293/ https://www.ncbi.nlm.nih.gov/pubmed/34794206 http://dx.doi.org/10.1111/cas.15204

Ejemplares similares

Antitumor activities of selective HSP90α/β inhibitor, TAS-116, in combination with bortezomib in multiple myeloma
por: Suzuki, Rikio, et al.
Publicado: (2014)

Antiobesity and Anti-Inflammatory Effects of Orally Administered Bonito Extracts on Mice Fed a High-Fat Diet
por: Ikebe, Emi, et al.
Publicado: (2017)

Optimizing antidotal treatment with the oral HSP90 inhibitor TAS-116 against hydrochloric acid-induced pulmonary fibrosis in mice
por: Solopov, Pavel A., et al.
Publicado: (2022)

Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia–lymphoma cells
por: Taniguchi, Hiroaki, et al.
Publicado: (2014)

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
por: Ranta-aho, Sofia, et al.
Publicado: (2021)

High resolution lectin microarray system for the ATL cell-typing and the evaluation of anti-cancer efficacy of medications
por: Iha, Hidekatsu, et al.
Publicado: (2014)

TAS-116 inhibits oncogenic KIT signalling on the Golgi in both imatinib-naïve and imatinib-resistant gastrointestinal stromal tumours
por: Saito, Yurina, et al.
Publicado: (2019)

A novel HSP90 inhibitor, 17-DMAG, induces Tax down-regulation and its oral administration to ATL-model mice intervenes against the infiltration property of the ATL-like lymphocytes and provides extended survival period
por: Ikebe, Emi, et al.
Publicado: (2014)

An open-label, crossover study to compare different formulations and evaluate effect of food on pharmacokinetics of pimitespib in patients with advanced solid tumors
por: Komatsu, Yoshito, et al.
Publicado: (2022)

Corrigendum to “Long-Term Potable Effects of Alkalescent Mineral Water on Intestinal Microbiota Shift and Physical Conditioning”
por: Yahiro, Takaaki, et al.
Publicado: (2020)

Long-Term Potable Effects of Alkalescent Mineral Water on Intestinal Microbiota Shift and Physical Conditioning
por: Yahiro, Takaaki, et al.
Publicado: (2019)

Long-term response to pimitespib in postoperative recurrent gastrointestinal stromal tumors with PDGFRA D842V mutation: a case report
por: Teranishi, Ryugo, et al.
Publicado: (2023)

Oligosecretory Primary Plasma Cell Leukemia with Atypical Morphological Abnormality
por: Toriyama, Eo, et al.
Publicado: (2019)

Increased serum vascular endothelial growth factor is associated with acute viral encephalitis in Bangladeshi children
por: Mori, Daisuke, et al.
Publicado: (2017)

Complete Sequences of the Human T-Cell Leukemia Virus Type 1 Proviral Genomes from Newly Established Adult T-Cell Leukemia Cell Lines in Oita Prefecture, Japan
por: Fukumoto, Takuro, et al.
Publicado: (2018)

Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1
por: Matsushita, Nobuko, et al.
Publicado: (2016)

Loss of NDRG2 enhanced activation of the NF-κB pathway by PTEN and NIK phosphorylation for ATL and other cancer development
por: Ichikawa, Tomonaga, et al.
Publicado: (2015)

RAISING is a high-performance method for identifying random transgene integration sites
por: Wada, Yusaku, et al.
Publicado: (2022)

Induction of apoptosis by HBI‐8000 in adult T‐cell leukemia/lymphoma is associated with activation of Bim and NLRP3
por: Hasegawa, Hiroo, et al.
Publicado: (2016)

Shieldings: TAS
Publicado: (2004)

Shieldings: TAS
Publicado: (2004)

Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys
por: Tsutsui, Kei, et al.
Publicado: (2016)

Evaluation of the efficacy and safety of TAS0313 in adults with recurrent glioblastoma
por: Narita, Yoshitaka, et al.
Publicado: (2022)

The Novel Link between Gene Expression Profiles of Adult T-Cell Leukemia/Lymphoma Patients’ Peripheral Blood Lymphocytes and Ferroptosis Susceptibility
por: Wang, Yu, et al.
Publicado: (2023)

Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells
por: Hirashita, Yuka, et al.
Publicado: (2016)

Commensal Microbiota Contributes to Chronic Endocarditis in TAX1BP1 Deficient Mice
por: Nakano, Satoko, et al.
Publicado: (2013)

Downregulation of dual‐specificity phosphatase 4 enhances cell proliferation and invasiveness in colorectal carcinomas
por: Ichimanda, Michihiro, et al.
Publicado: (2017)

The Contribution of Serum Complement Component 3 Levels to 90-Day Mortality in Living Donor Liver Transplantation
por: Fukui, Saeko, et al.
Publicado: (2021)

Corrigendum: The Contribution of Serum Complement Component 3 Levels to 90-Day Mortality in Living Donor Liver Transplantation
por: Fukui, Saeko, et al.
Publicado: (2022)

Vanillin Activates Human Bitter Taste Receptors TAS2R14, TAS2R20, and TAS2R39
por: Morini, Gabriella, et al.
Publicado: (2021)

Tas chebal : jun chajp a'tel pajbil /
por: González Dillon, Mónica
Publicado: (2013)

Functional divergence of the bitter receptor TAS2R38 in Sulawesi macaques
por: Widayati, Kanthi Arum, et al.
Publicado: (2019)

Performance evaluation of in vitro diagnostic kits for hepatitis B virus infection using the regional reference panel of Japan
por: Momose, Haruka, et al.
Publicado: (2023)

Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice
por: Ikebe, E, et al.
Publicado: (2013)

A Methodology for Assessing Tumor Clonality of Adult T Cell Leukemia/Lymphoma
por: Yamakawa, Tomohiro, et al.
Publicado: (2020)

Energy Deposition in the Triplet and TAS Issues
por: Broggi, F
Publicado: (2008)

Implementation of TasP: challenges and opportunities
por: Lange, Joep
Publicado: (2014)

TAS-102 and the quest for predictive biomarkers
por: van der Velden, Daphne L, et al.
Publicado: (2017)

Surveillance of norovirus among children with diarrhea in four major hospitals in Bhutan: Replacement of GII.21 by GII.3 as a dominant genotype
por: Wangchuk, Sonam, et al.
Publicado: (2017)

Cost-effectiveness of TAS-102 plus bevacizumab versus TAS-102 monotherapy in patients with metastatic colorectal cancer
por: Sugiura, Kiyoaki, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3debk9ipuig3v1e3gopt9q0v7f