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Biomolecular condensates in cancer biology
Understanding the characteristics of cancer cells is essential for the development of improved diagnosis and therapeutics. From a gene regulation perspective, the super‐enhancer concept has been introduced to systematically understand the molecular mechanisms underlying the identities of various cel...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819300/ https://www.ncbi.nlm.nih.gov/pubmed/34865286 http://dx.doi.org/10.1111/cas.15232 |
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author | Suzuki, Hiroshi I. Onimaru, Koh |
author_facet | Suzuki, Hiroshi I. Onimaru, Koh |
author_sort | Suzuki, Hiroshi I. |
collection | PubMed |
description | Understanding the characteristics of cancer cells is essential for the development of improved diagnosis and therapeutics. From a gene regulation perspective, the super‐enhancer concept has been introduced to systematically understand the molecular mechanisms underlying the identities of various cell types and has been extended to the analysis of cancer cells and cancer genome alterations. In addition, several characteristic features of super‐enhancers have led to the recognition of the link between gene regulation and biomolecular condensates, which is often mediated by liquid‐liquid phase separation. Several lines of evidence have suggested molecular and biophysical principles and their alterations in cancer cells, which are particularly associated with gene regulation and cell signaling (“ transcriptional” and “signaling” condensates). These findings collectively suggest that the modification of biomolecular condensates represents an important mechanism by which cancer cells acquire various cancer hallmark traits and establish functional innovation for cancer initiation and progression. The condensate model also provides the molecular basis of the vulnerability of cancer cells to transcriptional perturbation and further suggests the possibility of therapeutic targeting of condensates. This review summarizes recent findings regarding the relationships between super‐enhancers and biomolecular condensate models, multiple scenarios of condensate alterations in cancers, and the potential of the condensate model for therapeutic development. |
format | Online Article Text |
id | pubmed-8819300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88193002022-02-09 Biomolecular condensates in cancer biology Suzuki, Hiroshi I. Onimaru, Koh Cancer Sci Review Articles Understanding the characteristics of cancer cells is essential for the development of improved diagnosis and therapeutics. From a gene regulation perspective, the super‐enhancer concept has been introduced to systematically understand the molecular mechanisms underlying the identities of various cell types and has been extended to the analysis of cancer cells and cancer genome alterations. In addition, several characteristic features of super‐enhancers have led to the recognition of the link between gene regulation and biomolecular condensates, which is often mediated by liquid‐liquid phase separation. Several lines of evidence have suggested molecular and biophysical principles and their alterations in cancer cells, which are particularly associated with gene regulation and cell signaling (“ transcriptional” and “signaling” condensates). These findings collectively suggest that the modification of biomolecular condensates represents an important mechanism by which cancer cells acquire various cancer hallmark traits and establish functional innovation for cancer initiation and progression. The condensate model also provides the molecular basis of the vulnerability of cancer cells to transcriptional perturbation and further suggests the possibility of therapeutic targeting of condensates. This review summarizes recent findings regarding the relationships between super‐enhancers and biomolecular condensate models, multiple scenarios of condensate alterations in cancers, and the potential of the condensate model for therapeutic development. John Wiley and Sons Inc. 2021-12-14 2022-02 /pmc/articles/PMC8819300/ /pubmed/34865286 http://dx.doi.org/10.1111/cas.15232 Text en © 2021 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Review Articles Suzuki, Hiroshi I. Onimaru, Koh Biomolecular condensates in cancer biology |
title | Biomolecular condensates in cancer biology |
title_full | Biomolecular condensates in cancer biology |
title_fullStr | Biomolecular condensates in cancer biology |
title_full_unstemmed | Biomolecular condensates in cancer biology |
title_short | Biomolecular condensates in cancer biology |
title_sort | biomolecular condensates in cancer biology |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819300/ https://www.ncbi.nlm.nih.gov/pubmed/34865286 http://dx.doi.org/10.1111/cas.15232 |
work_keys_str_mv | AT suzukihiroshii biomolecularcondensatesincancerbiology AT onimarukoh biomolecularcondensatesincancerbiology |