Suppression of multiple anti‐apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms

Several lines of research suggest that Bcl‐xL‐mediated anti‐apoptotic effects may contribute to the pathogenesis of myeloproliferative neoplasms driven by JAK2V617F and serve as therapeutic target. Here, we used a knock‐in JAK2V617F mouse model and confirmed that Bcl‐xL was overexpressed in erythroi...

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Detalles Bibliográficos
Autores principales: Takei, Hisashi, Coelho‐Silva, Juan Luiz, Tavares Leal, Cristina, Queiroz Arantes Rocha, Adriana, Mantello Bianco, Thiago, Welner, Robert S., Mishima, Yuta, Kobayashi, Ikei S., Mullally, Ann, Lima, Keli, Machado‐Neto, João Agostinho, Kobayashi, Susumu S., Lobo de Figueiredo‐Pontes, Lorena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819353/
https://www.ncbi.nlm.nih.gov/pubmed/34808021
http://dx.doi.org/10.1111/cas.15210

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