Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction

Cytokine release syndrome (CRS) is a type of hypersensitivity reaction which has been previously described with chemotherapy and monoclonal antibodies, but not with antibiotics. We present 2 pediatric cases of Amoxicillin/Clavulanic acid (Augmentin) anaphylaxis resembling CRS. Both our patients pres...

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Autores principales: Tan, Lynette Liling, Lee, May Ping, Goh, Si Hui, Lim, Hwee Hoon, Goh, Anne, Chong, Kok Wee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819417/
https://www.ncbi.nlm.nih.gov/pubmed/35174060
http://dx.doi.org/10.5415/apallergy.2022.12.e9
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author Tan, Lynette Liling
Lee, May Ping
Goh, Si Hui
Lim, Hwee Hoon
Goh, Anne
Chong, Kok Wee
author_facet Tan, Lynette Liling
Lee, May Ping
Goh, Si Hui
Lim, Hwee Hoon
Goh, Anne
Chong, Kok Wee
author_sort Tan, Lynette Liling
collection PubMed
description Cytokine release syndrome (CRS) is a type of hypersensitivity reaction which has been previously described with chemotherapy and monoclonal antibodies, but not with antibiotics. We present 2 pediatric cases of Amoxicillin/Clavulanic acid (Augmentin) anaphylaxis resembling CRS. Both our patients presented during the index reaction with symptoms suggestive of an acute systemic inflammatory response mimicking sepsis. Their symptomology was reproducible at drug provocation test as anaphylaxis, but with suboptimal response to intramuscular adrenaline. Their infective workups were unremarkable and illnesses followed a self-limiting course. All these point towards a severe hypersensitivity reaction resembling CRS.
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spelling pubmed-88194172022-02-15 Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction Tan, Lynette Liling Lee, May Ping Goh, Si Hui Lim, Hwee Hoon Goh, Anne Chong, Kok Wee Asia Pac Allergy Hypothesis & Experience Cytokine release syndrome (CRS) is a type of hypersensitivity reaction which has been previously described with chemotherapy and monoclonal antibodies, but not with antibiotics. We present 2 pediatric cases of Amoxicillin/Clavulanic acid (Augmentin) anaphylaxis resembling CRS. Both our patients presented during the index reaction with symptoms suggestive of an acute systemic inflammatory response mimicking sepsis. Their symptomology was reproducible at drug provocation test as anaphylaxis, but with suboptimal response to intramuscular adrenaline. Their infective workups were unremarkable and illnesses followed a self-limiting course. All these point towards a severe hypersensitivity reaction resembling CRS. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2022-01-25 /pmc/articles/PMC8819417/ /pubmed/35174060 http://dx.doi.org/10.5415/apallergy.2022.12.e9 Text en Copyright © 2022. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Hypothesis & Experience
Tan, Lynette Liling
Lee, May Ping
Goh, Si Hui
Lim, Hwee Hoon
Goh, Anne
Chong, Kok Wee
Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction
title Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction
title_full Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction
title_fullStr Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction
title_full_unstemmed Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction
title_short Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction
title_sort cytokine release syndrome – a unique entity of augmentin hypersensitivity reaction
topic Hypothesis & Experience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819417/
https://www.ncbi.nlm.nih.gov/pubmed/35174060
http://dx.doi.org/10.5415/apallergy.2022.12.e9
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