Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction
Cytokine release syndrome (CRS) is a type of hypersensitivity reaction which has been previously described with chemotherapy and monoclonal antibodies, but not with antibiotics. We present 2 pediatric cases of Amoxicillin/Clavulanic acid (Augmentin) anaphylaxis resembling CRS. Both our patients pres...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Asia Pacific Association of Allergy, Asthma and Clinical Immunology
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819417/ https://www.ncbi.nlm.nih.gov/pubmed/35174060 http://dx.doi.org/10.5415/apallergy.2022.12.e9 |
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author | Tan, Lynette Liling Lee, May Ping Goh, Si Hui Lim, Hwee Hoon Goh, Anne Chong, Kok Wee |
author_facet | Tan, Lynette Liling Lee, May Ping Goh, Si Hui Lim, Hwee Hoon Goh, Anne Chong, Kok Wee |
author_sort | Tan, Lynette Liling |
collection | PubMed |
description | Cytokine release syndrome (CRS) is a type of hypersensitivity reaction which has been previously described with chemotherapy and monoclonal antibodies, but not with antibiotics. We present 2 pediatric cases of Amoxicillin/Clavulanic acid (Augmentin) anaphylaxis resembling CRS. Both our patients presented during the index reaction with symptoms suggestive of an acute systemic inflammatory response mimicking sepsis. Their symptomology was reproducible at drug provocation test as anaphylaxis, but with suboptimal response to intramuscular adrenaline. Their infective workups were unremarkable and illnesses followed a self-limiting course. All these point towards a severe hypersensitivity reaction resembling CRS. |
format | Online Article Text |
id | pubmed-8819417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Asia Pacific Association of Allergy, Asthma and Clinical Immunology |
record_format | MEDLINE/PubMed |
spelling | pubmed-88194172022-02-15 Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction Tan, Lynette Liling Lee, May Ping Goh, Si Hui Lim, Hwee Hoon Goh, Anne Chong, Kok Wee Asia Pac Allergy Hypothesis & Experience Cytokine release syndrome (CRS) is a type of hypersensitivity reaction which has been previously described with chemotherapy and monoclonal antibodies, but not with antibiotics. We present 2 pediatric cases of Amoxicillin/Clavulanic acid (Augmentin) anaphylaxis resembling CRS. Both our patients presented during the index reaction with symptoms suggestive of an acute systemic inflammatory response mimicking sepsis. Their symptomology was reproducible at drug provocation test as anaphylaxis, but with suboptimal response to intramuscular adrenaline. Their infective workups were unremarkable and illnesses followed a self-limiting course. All these point towards a severe hypersensitivity reaction resembling CRS. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2022-01-25 /pmc/articles/PMC8819417/ /pubmed/35174060 http://dx.doi.org/10.5415/apallergy.2022.12.e9 Text en Copyright © 2022. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Hypothesis & Experience Tan, Lynette Liling Lee, May Ping Goh, Si Hui Lim, Hwee Hoon Goh, Anne Chong, Kok Wee Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction |
title | Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction |
title_full | Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction |
title_fullStr | Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction |
title_full_unstemmed | Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction |
title_short | Cytokine release syndrome – a unique entity of Augmentin hypersensitivity reaction |
title_sort | cytokine release syndrome – a unique entity of augmentin hypersensitivity reaction |
topic | Hypothesis & Experience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819417/ https://www.ncbi.nlm.nih.gov/pubmed/35174060 http://dx.doi.org/10.5415/apallergy.2022.12.e9 |
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