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Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
Elesesterpenes A–K (1–11), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid were isolated from the leaves of Eleutherococcus sessiliflorus. Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819545/ https://www.ncbi.nlm.nih.gov/pubmed/35141205 http://dx.doi.org/10.3389/fchem.2021.813764 |
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author | Han, Dong Liu, Yan Li, Xiao-Mao Wang, Si-Yi Sun, Yan Algradi, Adnan Mohammed Zou, Hai-Dan Pan, Juan Guan, Wei Kuang, Hai-Xue Yang, Bing-You |
author_facet | Han, Dong Liu, Yan Li, Xiao-Mao Wang, Si-Yi Sun, Yan Algradi, Adnan Mohammed Zou, Hai-Dan Pan, Juan Guan, Wei Kuang, Hai-Xue Yang, Bing-You |
author_sort | Han, Dong |
collection | PubMed |
description | Elesesterpenes A–K (1–11), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid were isolated from the leaves of Eleutherococcus sessiliflorus. Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical, spectroscopic data. The absolute configuration of elesesterpenes A–B (1–2) was defined by single-crystal X-ray diffraction. Meanwhile, all the isolates were evaluated for anti-inflammatory activities on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells, and antiproliferative activities against human hepatoma (HepG2), human lung adenocarcinoma (A549), and human glioma cells (LN229) in vitro. It was found that some of them exhibited obvious anti-inflammatory activities and potent antiproliferative activities. |
format | Online Article Text |
id | pubmed-8819545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88195452022-02-08 Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus Han, Dong Liu, Yan Li, Xiao-Mao Wang, Si-Yi Sun, Yan Algradi, Adnan Mohammed Zou, Hai-Dan Pan, Juan Guan, Wei Kuang, Hai-Xue Yang, Bing-You Front Chem Chemistry Elesesterpenes A–K (1–11), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid were isolated from the leaves of Eleutherococcus sessiliflorus. Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical, spectroscopic data. The absolute configuration of elesesterpenes A–B (1–2) was defined by single-crystal X-ray diffraction. Meanwhile, all the isolates were evaluated for anti-inflammatory activities on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells, and antiproliferative activities against human hepatoma (HepG2), human lung adenocarcinoma (A549), and human glioma cells (LN229) in vitro. It was found that some of them exhibited obvious anti-inflammatory activities and potent antiproliferative activities. Frontiers Media S.A. 2022-01-24 /pmc/articles/PMC8819545/ /pubmed/35141205 http://dx.doi.org/10.3389/fchem.2021.813764 Text en Copyright © 2022 Han, Liu, Li, Wang, Sun, Algradi, Zou, Pan, Guan, Kuang and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Han, Dong Liu, Yan Li, Xiao-Mao Wang, Si-Yi Sun, Yan Algradi, Adnan Mohammed Zou, Hai-Dan Pan, Juan Guan, Wei Kuang, Hai-Xue Yang, Bing-You Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus |
title | Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
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title_full | Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
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title_fullStr | Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
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title_full_unstemmed | Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
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title_short | Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
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title_sort | elesesterpenes a–k: lupane-type triterpenoids from the leaves of eleutherococcus sessiliflorus |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819545/ https://www.ncbi.nlm.nih.gov/pubmed/35141205 http://dx.doi.org/10.3389/fchem.2021.813764 |
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