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Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus

Elesesterpenes A–K (1–11), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid were isolated from the leaves of Eleutherococcus sessiliflorus. Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical...

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Autores principales: Han, Dong, Liu, Yan, Li, Xiao-Mao, Wang, Si-Yi, Sun, Yan, Algradi, Adnan Mohammed, Zou, Hai-Dan, Pan, Juan, Guan, Wei, Kuang, Hai-Xue, Yang, Bing-You
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819545/
https://www.ncbi.nlm.nih.gov/pubmed/35141205
http://dx.doi.org/10.3389/fchem.2021.813764
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author Han, Dong
Liu, Yan
Li, Xiao-Mao
Wang, Si-Yi
Sun, Yan
Algradi, Adnan Mohammed
Zou, Hai-Dan
Pan, Juan
Guan, Wei
Kuang, Hai-Xue
Yang, Bing-You
author_facet Han, Dong
Liu, Yan
Li, Xiao-Mao
Wang, Si-Yi
Sun, Yan
Algradi, Adnan Mohammed
Zou, Hai-Dan
Pan, Juan
Guan, Wei
Kuang, Hai-Xue
Yang, Bing-You
author_sort Han, Dong
collection PubMed
description Elesesterpenes A–K (1–11), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid were isolated from the leaves of Eleutherococcus sessiliflorus. Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical, spectroscopic data. The absolute configuration of elesesterpenes A–B (1–2) was defined by single-crystal X-ray diffraction. Meanwhile, all the isolates were evaluated for anti-inflammatory activities on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells, and antiproliferative activities against human hepatoma (HepG2), human lung adenocarcinoma (A549), and human glioma cells (LN229) in vitro. It was found that some of them exhibited obvious anti-inflammatory activities and potent antiproliferative activities.
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spelling pubmed-88195452022-02-08 Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus Han, Dong Liu, Yan Li, Xiao-Mao Wang, Si-Yi Sun, Yan Algradi, Adnan Mohammed Zou, Hai-Dan Pan, Juan Guan, Wei Kuang, Hai-Xue Yang, Bing-You Front Chem Chemistry Elesesterpenes A–K (1–11), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid were isolated from the leaves of Eleutherococcus sessiliflorus. Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical, spectroscopic data. The absolute configuration of elesesterpenes A–B (1–2) was defined by single-crystal X-ray diffraction. Meanwhile, all the isolates were evaluated for anti-inflammatory activities on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells, and antiproliferative activities against human hepatoma (HepG2), human lung adenocarcinoma (A549), and human glioma cells (LN229) in vitro. It was found that some of them exhibited obvious anti-inflammatory activities and potent antiproliferative activities. Frontiers Media S.A. 2022-01-24 /pmc/articles/PMC8819545/ /pubmed/35141205 http://dx.doi.org/10.3389/fchem.2021.813764 Text en Copyright © 2022 Han, Liu, Li, Wang, Sun, Algradi, Zou, Pan, Guan, Kuang and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Han, Dong
Liu, Yan
Li, Xiao-Mao
Wang, Si-Yi
Sun, Yan
Algradi, Adnan Mohammed
Zou, Hai-Dan
Pan, Juan
Guan, Wei
Kuang, Hai-Xue
Yang, Bing-You
Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
title Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
title_full Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
title_fullStr Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
title_full_unstemmed Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
title_short Elesesterpenes A–K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus
title_sort elesesterpenes a–k: lupane-type triterpenoids from the leaves of eleutherococcus sessiliflorus
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819545/
https://www.ncbi.nlm.nih.gov/pubmed/35141205
http://dx.doi.org/10.3389/fchem.2021.813764
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