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Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD

OBJECTIVES: Our aim was to study the associations between resting lung hyperinflation, weight-bearing exercise-induced dyspnea and adipose distribution in obese and normal-weight COPD patients. METHODS: We performed a comparison between 80 obese COPD patients (COPD(OB)) with 80 age- and FEV(1) match...

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Autores principales: S, Zewari, B, van den Borst, FJ, van den Elshout, JH, Vercoulen, PN, Dekhuijzen, YF, Heijdra, PJ, Vos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819751/
https://www.ncbi.nlm.nih.gov/pubmed/35125014
http://dx.doi.org/10.1177/14799731211052305
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author S, Zewari
B, van den Borst
FJ, van den Elshout
JH, Vercoulen
PN, Dekhuijzen
YF, Heijdra
PJ, Vos
author_facet S, Zewari
B, van den Borst
FJ, van den Elshout
JH, Vercoulen
PN, Dekhuijzen
YF, Heijdra
PJ, Vos
author_sort S, Zewari
collection PubMed
description OBJECTIVES: Our aim was to study the associations between resting lung hyperinflation, weight-bearing exercise-induced dyspnea and adipose distribution in obese and normal-weight COPD patients. METHODS: We performed a comparison between 80 obese COPD patients (COPD(OB)) with 80 age- and FEV(1) matched normal-weight COPD patients (COPD(NW)). Dyspnea was assessed by the mMRC scale and the Borg dyspnea score before and after a 6 min walk test. Further characterization included spirometry, body plethysmography and metronome paced tachypnea (MPT) to estimate dynamic hyperinflation. Body composition was assessed with bioelectrical impedance analysis. Associations between dyspnea scores and BMI and body composition groups were studied using logistic regression models. RESULTS: COPD(OB) patients had attenuated increases in TLC, FRC and RV compared to COPD(NW) patients (p < 0.01). The groups had comparable 6 min walking distance and ΔFRC upon MPT (p > 0.05). Compared to COPD(NW), COPD(OB) patients reported more often a mMRC ≥ 2 (65 vs 46%; p = 0.02; OR 3.0, 95% CI 1.4–6.2, p < 0.01) and had higher ΔBorg upon 6MWT: 2.0 (SEM 0.20) vs. 1.4 (SEM 0.16), p = 0.01; OR for ΔBorg ≥ 2: 2.4, 95% CI 1.1–5.2, p = 0.03. Additional logistic regression analyses on the associations between body composition and dyspnea indicated that increased body fat percentage, fat mass index and waist-to-hip ratio were associated with higher ORs for mMRC ≥ 2 and ΔBorg upon 6MWT ≥ 2. CONCLUSION: Despite its beneficial effect on resting lung hyperinflation, adiposity is associated with increased weight-bearing exercise-induced dyspnea in COPD.
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spelling pubmed-88197512022-02-08 Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD S, Zewari B, van den Borst FJ, van den Elshout JH, Vercoulen PN, Dekhuijzen YF, Heijdra PJ, Vos Chron Respir Dis Original Paper OBJECTIVES: Our aim was to study the associations between resting lung hyperinflation, weight-bearing exercise-induced dyspnea and adipose distribution in obese and normal-weight COPD patients. METHODS: We performed a comparison between 80 obese COPD patients (COPD(OB)) with 80 age- and FEV(1) matched normal-weight COPD patients (COPD(NW)). Dyspnea was assessed by the mMRC scale and the Borg dyspnea score before and after a 6 min walk test. Further characterization included spirometry, body plethysmography and metronome paced tachypnea (MPT) to estimate dynamic hyperinflation. Body composition was assessed with bioelectrical impedance analysis. Associations between dyspnea scores and BMI and body composition groups were studied using logistic regression models. RESULTS: COPD(OB) patients had attenuated increases in TLC, FRC and RV compared to COPD(NW) patients (p < 0.01). The groups had comparable 6 min walking distance and ΔFRC upon MPT (p > 0.05). Compared to COPD(NW), COPD(OB) patients reported more often a mMRC ≥ 2 (65 vs 46%; p = 0.02; OR 3.0, 95% CI 1.4–6.2, p < 0.01) and had higher ΔBorg upon 6MWT: 2.0 (SEM 0.20) vs. 1.4 (SEM 0.16), p = 0.01; OR for ΔBorg ≥ 2: 2.4, 95% CI 1.1–5.2, p = 0.03. Additional logistic regression analyses on the associations between body composition and dyspnea indicated that increased body fat percentage, fat mass index and waist-to-hip ratio were associated with higher ORs for mMRC ≥ 2 and ΔBorg upon 6MWT ≥ 2. CONCLUSION: Despite its beneficial effect on resting lung hyperinflation, adiposity is associated with increased weight-bearing exercise-induced dyspnea in COPD. SAGE Publications 2022-02-05 /pmc/articles/PMC8819751/ /pubmed/35125014 http://dx.doi.org/10.1177/14799731211052305 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Paper
S, Zewari
B, van den Borst
FJ, van den Elshout
JH, Vercoulen
PN, Dekhuijzen
YF, Heijdra
PJ, Vos
Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD
title Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD
title_full Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD
title_fullStr Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD
title_full_unstemmed Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD
title_short Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD
title_sort adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in copd
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819751/
https://www.ncbi.nlm.nih.gov/pubmed/35125014
http://dx.doi.org/10.1177/14799731211052305
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