Cargando…
Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD
OBJECTIVES: Our aim was to study the associations between resting lung hyperinflation, weight-bearing exercise-induced dyspnea and adipose distribution in obese and normal-weight COPD patients. METHODS: We performed a comparison between 80 obese COPD patients (COPD(OB)) with 80 age- and FEV(1) match...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819751/ https://www.ncbi.nlm.nih.gov/pubmed/35125014 http://dx.doi.org/10.1177/14799731211052305 |
_version_ | 1784646112649412608 |
---|---|
author | S, Zewari B, van den Borst FJ, van den Elshout JH, Vercoulen PN, Dekhuijzen YF, Heijdra PJ, Vos |
author_facet | S, Zewari B, van den Borst FJ, van den Elshout JH, Vercoulen PN, Dekhuijzen YF, Heijdra PJ, Vos |
author_sort | S, Zewari |
collection | PubMed |
description | OBJECTIVES: Our aim was to study the associations between resting lung hyperinflation, weight-bearing exercise-induced dyspnea and adipose distribution in obese and normal-weight COPD patients. METHODS: We performed a comparison between 80 obese COPD patients (COPD(OB)) with 80 age- and FEV(1) matched normal-weight COPD patients (COPD(NW)). Dyspnea was assessed by the mMRC scale and the Borg dyspnea score before and after a 6 min walk test. Further characterization included spirometry, body plethysmography and metronome paced tachypnea (MPT) to estimate dynamic hyperinflation. Body composition was assessed with bioelectrical impedance analysis. Associations between dyspnea scores and BMI and body composition groups were studied using logistic regression models. RESULTS: COPD(OB) patients had attenuated increases in TLC, FRC and RV compared to COPD(NW) patients (p < 0.01). The groups had comparable 6 min walking distance and ΔFRC upon MPT (p > 0.05). Compared to COPD(NW), COPD(OB) patients reported more often a mMRC ≥ 2 (65 vs 46%; p = 0.02; OR 3.0, 95% CI 1.4–6.2, p < 0.01) and had higher ΔBorg upon 6MWT: 2.0 (SEM 0.20) vs. 1.4 (SEM 0.16), p = 0.01; OR for ΔBorg ≥ 2: 2.4, 95% CI 1.1–5.2, p = 0.03. Additional logistic regression analyses on the associations between body composition and dyspnea indicated that increased body fat percentage, fat mass index and waist-to-hip ratio were associated with higher ORs for mMRC ≥ 2 and ΔBorg upon 6MWT ≥ 2. CONCLUSION: Despite its beneficial effect on resting lung hyperinflation, adiposity is associated with increased weight-bearing exercise-induced dyspnea in COPD. |
format | Online Article Text |
id | pubmed-8819751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-88197512022-02-08 Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD S, Zewari B, van den Borst FJ, van den Elshout JH, Vercoulen PN, Dekhuijzen YF, Heijdra PJ, Vos Chron Respir Dis Original Paper OBJECTIVES: Our aim was to study the associations between resting lung hyperinflation, weight-bearing exercise-induced dyspnea and adipose distribution in obese and normal-weight COPD patients. METHODS: We performed a comparison between 80 obese COPD patients (COPD(OB)) with 80 age- and FEV(1) matched normal-weight COPD patients (COPD(NW)). Dyspnea was assessed by the mMRC scale and the Borg dyspnea score before and after a 6 min walk test. Further characterization included spirometry, body plethysmography and metronome paced tachypnea (MPT) to estimate dynamic hyperinflation. Body composition was assessed with bioelectrical impedance analysis. Associations between dyspnea scores and BMI and body composition groups were studied using logistic regression models. RESULTS: COPD(OB) patients had attenuated increases in TLC, FRC and RV compared to COPD(NW) patients (p < 0.01). The groups had comparable 6 min walking distance and ΔFRC upon MPT (p > 0.05). Compared to COPD(NW), COPD(OB) patients reported more often a mMRC ≥ 2 (65 vs 46%; p = 0.02; OR 3.0, 95% CI 1.4–6.2, p < 0.01) and had higher ΔBorg upon 6MWT: 2.0 (SEM 0.20) vs. 1.4 (SEM 0.16), p = 0.01; OR for ΔBorg ≥ 2: 2.4, 95% CI 1.1–5.2, p = 0.03. Additional logistic regression analyses on the associations between body composition and dyspnea indicated that increased body fat percentage, fat mass index and waist-to-hip ratio were associated with higher ORs for mMRC ≥ 2 and ΔBorg upon 6MWT ≥ 2. CONCLUSION: Despite its beneficial effect on resting lung hyperinflation, adiposity is associated with increased weight-bearing exercise-induced dyspnea in COPD. SAGE Publications 2022-02-05 /pmc/articles/PMC8819751/ /pubmed/35125014 http://dx.doi.org/10.1177/14799731211052305 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Paper S, Zewari B, van den Borst FJ, van den Elshout JH, Vercoulen PN, Dekhuijzen YF, Heijdra PJ, Vos Adiposity increases weight-bearing exercise-induced dyspnea despite favoring resting lung hyperinflation in COPD |
title | Adiposity increases weight-bearing exercise-induced dyspnea despite
favoring resting lung hyperinflation in COPD |
title_full | Adiposity increases weight-bearing exercise-induced dyspnea despite
favoring resting lung hyperinflation in COPD |
title_fullStr | Adiposity increases weight-bearing exercise-induced dyspnea despite
favoring resting lung hyperinflation in COPD |
title_full_unstemmed | Adiposity increases weight-bearing exercise-induced dyspnea despite
favoring resting lung hyperinflation in COPD |
title_short | Adiposity increases weight-bearing exercise-induced dyspnea despite
favoring resting lung hyperinflation in COPD |
title_sort | adiposity increases weight-bearing exercise-induced dyspnea despite
favoring resting lung hyperinflation in copd |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8819751/ https://www.ncbi.nlm.nih.gov/pubmed/35125014 http://dx.doi.org/10.1177/14799731211052305 |
work_keys_str_mv | AT szewari adiposityincreasesweightbearingexerciseinduceddyspneadespitefavoringrestinglunghyperinflationincopd AT bvandenborst adiposityincreasesweightbearingexerciseinduceddyspneadespitefavoringrestinglunghyperinflationincopd AT fjvandenelshout adiposityincreasesweightbearingexerciseinduceddyspneadespitefavoringrestinglunghyperinflationincopd AT jhvercoulen adiposityincreasesweightbearingexerciseinduceddyspneadespitefavoringrestinglunghyperinflationincopd AT pndekhuijzen adiposityincreasesweightbearingexerciseinduceddyspneadespitefavoringrestinglunghyperinflationincopd AT yfheijdra adiposityincreasesweightbearingexerciseinduceddyspneadespitefavoringrestinglunghyperinflationincopd AT pjvos adiposityincreasesweightbearingexerciseinduceddyspneadespitefavoringrestinglunghyperinflationincopd |