Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment

This review considers the similarities and differences between the physiological systems regulated by gut‐derived and neuronally produced glucagon‐like peptide 1 (GLP‐1). It addresses the questions of whether peripheral and central GLP‐1 sources constitute separate, linked or redundant systems and w...

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Detalles Bibliográficos
Autores principales: Trapp, Stefan, Brierley, Daniel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
GLP1 RECEPTOR LIGANDS (BJP 75th ANNIVERSARY) ‐ THEMED ISSUE REVIEWS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820179/
https://www.ncbi.nlm.nih.gov/pubmed/34323288
http://dx.doi.org/10.1111/bph.15638
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author Trapp, Stefan
Brierley, Daniel I.
author_facet Trapp, Stefan
Brierley, Daniel I.
author_sort Trapp, Stefan
collection PubMed
description This review considers the similarities and differences between the physiological systems regulated by gut‐derived and neuronally produced glucagon‐like peptide 1 (GLP‐1). It addresses the questions of whether peripheral and central GLP‐1 sources constitute separate, linked or redundant systems and whether the brain GLP‐1 system consists of disparate sections or is a homogenous entity. This review also explores the implications of the answers to these questions for the use of GLP‐1 receptor agonists as anti‐obesity drugs. LINKED ARTICLES: This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.4/issuetoc
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spelling pubmed-88201792022-02-11 Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment Trapp, Stefan Brierley, Daniel I. Br J Pharmacol GLP1 RECEPTOR LIGANDS (BJP 75th ANNIVERSARY) ‐ THEMED ISSUE REVIEWS This review considers the similarities and differences between the physiological systems regulated by gut‐derived and neuronally produced glucagon‐like peptide 1 (GLP‐1). It addresses the questions of whether peripheral and central GLP‐1 sources constitute separate, linked or redundant systems and whether the brain GLP‐1 system consists of disparate sections or is a homogenous entity. This review also explores the implications of the answers to these questions for the use of GLP‐1 receptor agonists as anti‐obesity drugs. LINKED ARTICLES: This article is part of a themed issue on GLP1 receptor ligands (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.4/issuetoc John Wiley and Sons Inc. 2021-08-28 2022-02 /pmc/articles/PMC8820179/ /pubmed/34323288 http://dx.doi.org/10.1111/bph.15638 Text en © 2021 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle GLP1 RECEPTOR LIGANDS (BJP 75th ANNIVERSARY) ‐ THEMED ISSUE REVIEWS
Trapp, Stefan
Brierley, Daniel I.
Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment
title Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment
title_full Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment
title_fullStr Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment
title_full_unstemmed Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment
title_short Brain GLP‐1 and the regulation of food intake: GLP‐1 action in the brain and its implications for GLP‐1 receptor agonists in obesity treatment
title_sort brain glp‐1 and the regulation of food intake: glp‐1 action in the brain and its implications for glp‐1 receptor agonists in obesity treatment
topic GLP1 RECEPTOR LIGANDS (BJP 75th ANNIVERSARY) ‐ THEMED ISSUE REVIEWS
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820179/
https://www.ncbi.nlm.nih.gov/pubmed/34323288
http://dx.doi.org/10.1111/bph.15638
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