Cargando…

Gut Microbiota Regulates the Sympathetic Nerve Activity and Peripheral Serotonin Through Hypothalamic MicroRNA-204 in Order to Increase the Browning of White Adipose Tissue in Obesity

The prevalence of obesity is increasing worldwide, and novel therapeutic strategies such as enhancement of thermogenic pathways in white adipose tissue (WAT) are gaining more attention. The gut/brain axis plays an essential role in promoting the browning of WAT. However, the mechanism by which this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kassan, Adam, Ait-Aissa, Karima, Kassan, Modar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cureus 2022
Materias:	Endocrinology/Diabetes/Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820388/ https://www.ncbi.nlm.nih.gov/pubmed/35155042 http://dx.doi.org/10.7759/cureus.21913

Ejemplares similares

Hypothalamic miR-204 Induces Alteration of Heart Electrophysiology and Neurogenic Hypertension by Regulating the Sympathetic Nerve Activity: Potential Role of Microbiota
por: Kassan, Adam, et al.
Publicado: (2021)

The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr(−/−) Mice with Obesity
por: Munkhsaikhan, Undral, et al.
Publicado: (2023)

Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2
por: Kassan, Modar, et al.
Publicado: (2023)

Association of Cardiotoxicity With Doxorubicin and Trastuzumab: A Double-Edged Sword in Chemotherapy
por: Gabani, Mohanad, et al.
Publicado: (2021)

MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy
por: Ait-Aissa, Karima, et al.
Publicado: (2020)

Corrigendum: Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress
por: Kassan, Modar, et al.
Publicado: (2017)

Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1
por: Vikram, Ajit, et al.
Publicado: (2016)

MicroRNA-204 promotes vascular endoplasmic reticulum stress and endothelial dysfunction by targeting Sirtuin1
por: Kassan, Modar, et al.
Publicado: (2017)

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin
por: Rahmouni, Kamal, et al.
Publicado: (2009)

Endoplasmic Reticulum Stress and Microvascular Endothelial Dysfunction in Diabetes
por: Kassan, Modar, et al.
Publicado: (2011)

ODP204 Hemochromatosis and endocrine dysfunctions – a case report
por: Carvalho, Davide, et al.
Publicado: (2022)

Sirtuin1 protects endothelial Caveolin-1 expression and preserves endothelial function via suppressing miR-204 and endoplasmic reticulum stress
por: Kassan, M., et al.
Publicado: (2017)

(Pro)renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells
por: Reyes-Martinez, Cristian, et al.
Publicado: (2019)

Microbiota-governed microRNA-204 impairs endothelial function and blood pressure decline during inactivity in db/db mice
por: Gaddam, Ravinder Reddy, et al.
Publicado: (2020)

Sex differences in sympathetic innervation and browning of white adipose tissue of mice
por: Kim, Sang-Nam, et al.
Publicado: (2016)

Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System
por: Bruinstroop, Eveline, et al.
Publicado: (2012)

KSRP Ablation Enhances Brown Fat Gene Program in White Adipose Tissue Through Reduced miR-150 Expression
por: Chou, Chu-Fang, et al.
Publicado: (2014)

Activated brown adipose tissue releases exosomes containing mitochondrial methylene tetrahydrofolate dehydrogenase (NADP dependent) 1-like protein (MTHFD1L)
por: Leow, Melvin Khee-Shing, et al.
Publicado: (2022)

Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue
por: Kong, Xiaocen, et al.
Publicado: (2015)

HOXC10 Suppresses Browning to Maintain White Adipocyte Identity
por: Tan, H.Y. Angeline, et al.
Publicado: (2021)

RF16 | PSUN204 Improving Inpatient Insulin Management amongst Internal Medicine Residents with a Multi-Media Structured Educational Program
por: Pennant, Marjorie, et al.
Publicado: (2022)

SAT051 The Effect Of High Fat Diet On Insulin Signaling In White Adipose Tissue Of Liver Androgen Receptor Knockout In Male Mice
por: O'neil Hill-Dick, Johvan, et al.
Publicado: (2023)

SAT055 The Effect Of High Fat Diet On Insulin Signaling In White Adipose Tissue Of Liver Androgen Receptor Knockout In Female Mice
por: Bolarinwa, Elizabeth, et al.
Publicado: (2023)

Temperature-Acclimated Brown Adipose Tissue Modulates Insulin Sensitivity in Humans
por: Lee, Paul, et al.
Publicado: (2014)

Reducing RIP140 Expression in Macrophage Alters ATM Infiltration, Facilitates White Adipose Tissue Browning, and Prevents High-Fat Diet–Induced Insulin Resistance
por: Liu, Pu-Ste, et al.
Publicado: (2014)

Raise capital on your own terms: how to fund your business without selling your soul
por: Kassan, Jenny
Publicado: (2017)

Astragalus polysaccharide attenuates metabolic memory-triggered ER stress and apoptosis via regulation of miR-204/SIRT1 axis in retinal pigment epithelial cells
por: Peng, Qing-Hua, et al.
Publicado: (2020)

Chronic Kidney Disease Presenting With Brown Tumors in the Mandible
por: Singh, Sumedha, et al.
Publicado: (2022)

Brown Rice and Its Component, γ-Oryzanol, Attenuate the Preference for High-Fat Diet by Decreasing Hypothalamic Endoplasmic Reticulum Stress in Mice
por: Kozuka, Chisayo, et al.
Publicado: (2012)

OR12-05 Blunting Of Sympathetic Activation Of Pancreas As A Cause For Hypoglycemic Unawareness In Hypoglycemia Associated Autonomic Failure
por: Thakkar, Keya, et al.
Publicado: (2023)

Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation
por: Choi, Hyunjung, et al.
Publicado: (2018)

Hypothalamic control of brown adipose tissue thermogenesis
por: Labbé, Sebastien M., et al.
Publicado: (2015)

Systemic β-Adrenergic Stimulation of Thermogenesis Is Not Accompanied by Brown Adipose Tissue Activity in Humans
por: Vosselman, Maarten J., et al.
Publicado: (2012)

Brown Adipose Tissue Improves Whole-Body Glucose Homeostasis and Insulin Sensitivity in Humans
por: Chondronikola, Maria, et al.
Publicado: (2014)

Characterization of Viral Insulin-Like Peptides Reveals Unique White Adipose Tissue Specific Characteristics
por: Chrudinova, Martina, et al.
Publicado: (2021)

Brown Tumor With Spine Involvement at Multiple Levels in a Hemodialysis Patient
por: Ghernautan, Victoria, et al.
Publicado: (2021)

Spontaneous Regression of Brown Tumor in a Patient Treated With Peritoneal Dialysis
por: Ito, Kan, et al.
Publicado: (2021)

Multiple Brown Tumors Secondary to Parathyroid Carcinoma: A Challenging Diagnosis
por: Silva, Eugénia, et al.
Publicado: (2022)

Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation, Autonomic Dysregulation, and Neuroendocrine Tumor (ROHHADNET) Syndrome: A Case Report
por: Aldirawi, Mohammed, et al.
Publicado: (2023)

Sympathetic innervation of the interscapular brown adipose tissue in mouse
por: François, Marie, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_os7jm0mksfdfnsov0dblci6rp2