Machine learning-driven identification of drugs inhibiting cytochrome P450 2C9

Cytochrome P450 2C9 (CYP2C9) is a major drug-metabolizing enzyme that represents 20% of the hepatic CYPs and is responsible for the metabolism of 15% of drugs. A general concern in drug discovery is to avoid the inhibition of CYP leading to toxic drug accumulation and adverse drug–drug interactions....

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Detalles Bibliográficos
Autores principales: Goldwaser, Elodie, Laurent, Catherine, Lagarde, Nathalie, Fabrega, Sylvie, Nay, Laure, Villoutreix, Bruno O., Jelsch, Christian, Nicot, Arnaud B., Loriot, Marie-Anne, Miteva, Maria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820617/
https://www.ncbi.nlm.nih.gov/pubmed/35081108
http://dx.doi.org/10.1371/journal.pcbi.1009820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820617/
https://www.ncbi.nlm.nih.gov/pubmed/35081108
http://dx.doi.org/10.1371/journal.pcbi.1009820

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