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Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells

Research into the metabolism of the non-essential amino acid (NEAA) proline in cancer has gained traction in recent years. The last step in the proline biosynthesis pathway is catalyzed by pyrroline-5-carboxylate reductase (PYCR) enzymes. There are three PYCR enzymes: mitochondrial PYCR1 and 2 and c...

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Detalles Bibliográficos
Autores principales:	Alaqbi, Saif Sattar, Burke, Lynsey, Guterman, Inna, Green, Caleb, West, Kevin, Palacios-Gallego, Raquel, Cai, Hong, Alexandrou, Constantinos, Myint, Ni Ni Moe, Parrott, Emma, Howells, Lynne M., Higgins, Jennifer A., Jones, Donald J. L., Singh, Rajinder, Britton, Robert G., Tufarelli, Cristina, Thomas, Anne, Rufini, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820619/ https://www.ncbi.nlm.nih.gov/pubmed/35130302 http://dx.doi.org/10.1371/journal.pone.0262364

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