A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection

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Precise characterization and targeting of host cell transcriptional machinery hijacked by viral infection remains challenging. Here, we show that SARS-CoV-2 hijacks the host cell transcriptional machinery to induce a phenotypic state amenable to its replication. Specifically, analysis of Master Regu...

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Detalles Bibliográficos
Autores principales: Laise, Pasquale, Stanifer, Megan L., Bosker, Gideon, Sun, Xiaoyun, Triana, Sergio, Doldan, Patricio, La Manna, Federico, De Menna, Marta, Realubit, Ronald B., Pampou, Sergey, Karan, Charles, Alexandrov, Theodore, Kruithof-de Julio, Marianna, Califano, Andrea, Boulant, Steeve, Alvarez, Mariano J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820669/
https://www.ncbi.nlm.nih.gov/pubmed/35132404
http://dx.doi.org/10.21203/rs.3.rs-1287631/v1

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