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Effect of Short-term Homebased Pre- and Postoperative Exercise on Recovery After Colorectal Cancer Surgery (PHYSSURG-C): A Randomized Clinical Trial

OBJECTIVE: To determine the effect of a short-term, unsupervised exercise intervention before and after colorectal cancer surgery on self-assessed physical recovery. SUMMARY OF BACKGROUND DATA: Preoperative exercise interventions could help improve recovery after colorectal cancer surgery and is cur...

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Autores principales: Onerup, Aron, Andersson, John, Angenete, Eva, Bock, David, Börjesson, Mats, Ehrencrona, Carolina, Fagevik Olsén, Monika, Larsson, Per-Anders, de la Croix, Hanna, Wedin, Anette, Haglind, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820776/
https://www.ncbi.nlm.nih.gov/pubmed/33843798
http://dx.doi.org/10.1097/SLA.0000000000004901
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author Onerup, Aron
Andersson, John
Angenete, Eva
Bock, David
Börjesson, Mats
Ehrencrona, Carolina
Fagevik Olsén, Monika
Larsson, Per-Anders
de la Croix, Hanna
Wedin, Anette
Haglind, Eva
author_facet Onerup, Aron
Andersson, John
Angenete, Eva
Bock, David
Börjesson, Mats
Ehrencrona, Carolina
Fagevik Olsén, Monika
Larsson, Per-Anders
de la Croix, Hanna
Wedin, Anette
Haglind, Eva
author_sort Onerup, Aron
collection PubMed
description OBJECTIVE: To determine the effect of a short-term, unsupervised exercise intervention before and after colorectal cancer surgery on self-assessed physical recovery. SUMMARY OF BACKGROUND DATA: Preoperative exercise interventions could help improve recovery after colorectal cancer surgery and is currently recommended. METHODS: A randomized, parallel, open-label trial in six university or regional hospitals in Sweden. Inclusion criteria were age ≥20 years and planned elective colorectal cancer surgery. Participants were randomized to either a physical activity intervention with aerobic activity and inspiratory muscle training 2 weeks pre- and 4 weeks postoperatively or usual care. The primary outcome measure was self-assessed physical recovery 4 weeks postoperatively. Analyses were performed according to intention to treat. Outcome assessors were masked regarding the intervention while both participants and physiotherapists were informed due to the nature of the intervention. RESULTS: Between January 22, 2015, and May 28, 2020, 761 participants were recruited and assigned to either intervention (I) (n = 379) or control (C) (n = 382). After exclusions 668 participants (I = 317, C = 351) were included in the primary analysis. There was no effect from the intervention on the primary outcome measure (adjusted odds ratio 0.84, 95% confidence interval 0.62–1.15) with 13% and 15% of participants feeling fully physically recovered in I and C, respectively. There were no reported adverse events. CONCLUSIONS: There was no effect from a physical activity intervention before and after colorectal cancer surgery on short-term self-assessed physical recovery. The results from this study call for reconsiderations regarding current recommendations for preoperative physical activity interventions.
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spelling pubmed-88207762022-02-09 Effect of Short-term Homebased Pre- and Postoperative Exercise on Recovery After Colorectal Cancer Surgery (PHYSSURG-C): A Randomized Clinical Trial Onerup, Aron Andersson, John Angenete, Eva Bock, David Börjesson, Mats Ehrencrona, Carolina Fagevik Olsén, Monika Larsson, Per-Anders de la Croix, Hanna Wedin, Anette Haglind, Eva Ann Surg Randomized Controlled Trials OBJECTIVE: To determine the effect of a short-term, unsupervised exercise intervention before and after colorectal cancer surgery on self-assessed physical recovery. SUMMARY OF BACKGROUND DATA: Preoperative exercise interventions could help improve recovery after colorectal cancer surgery and is currently recommended. METHODS: A randomized, parallel, open-label trial in six university or regional hospitals in Sweden. Inclusion criteria were age ≥20 years and planned elective colorectal cancer surgery. Participants were randomized to either a physical activity intervention with aerobic activity and inspiratory muscle training 2 weeks pre- and 4 weeks postoperatively or usual care. The primary outcome measure was self-assessed physical recovery 4 weeks postoperatively. Analyses were performed according to intention to treat. Outcome assessors were masked regarding the intervention while both participants and physiotherapists were informed due to the nature of the intervention. RESULTS: Between January 22, 2015, and May 28, 2020, 761 participants were recruited and assigned to either intervention (I) (n = 379) or control (C) (n = 382). After exclusions 668 participants (I = 317, C = 351) were included in the primary analysis. There was no effect from the intervention on the primary outcome measure (adjusted odds ratio 0.84, 95% confidence interval 0.62–1.15) with 13% and 15% of participants feeling fully physically recovered in I and C, respectively. There were no reported adverse events. CONCLUSIONS: There was no effect from a physical activity intervention before and after colorectal cancer surgery on short-term self-assessed physical recovery. The results from this study call for reconsiderations regarding current recommendations for preoperative physical activity interventions. Lippincott Williams & Wilkins 2022-03 2021-04-09 /pmc/articles/PMC8820776/ /pubmed/33843798 http://dx.doi.org/10.1097/SLA.0000000000004901 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Randomized Controlled Trials
Onerup, Aron
Andersson, John
Angenete, Eva
Bock, David
Börjesson, Mats
Ehrencrona, Carolina
Fagevik Olsén, Monika
Larsson, Per-Anders
de la Croix, Hanna
Wedin, Anette
Haglind, Eva
Effect of Short-term Homebased Pre- and Postoperative Exercise on Recovery After Colorectal Cancer Surgery (PHYSSURG-C): A Randomized Clinical Trial
title Effect of Short-term Homebased Pre- and Postoperative Exercise on Recovery After Colorectal Cancer Surgery (PHYSSURG-C): A Randomized Clinical Trial
title_full Effect of Short-term Homebased Pre- and Postoperative Exercise on Recovery After Colorectal Cancer Surgery (PHYSSURG-C): A Randomized Clinical Trial
title_fullStr Effect of Short-term Homebased Pre- and Postoperative Exercise on Recovery After Colorectal Cancer Surgery (PHYSSURG-C): A Randomized Clinical Trial
title_full_unstemmed Effect of Short-term Homebased Pre- and Postoperative Exercise on Recovery After Colorectal Cancer Surgery (PHYSSURG-C): A Randomized Clinical Trial
title_short Effect of Short-term Homebased Pre- and Postoperative Exercise on Recovery After Colorectal Cancer Surgery (PHYSSURG-C): A Randomized Clinical Trial
title_sort effect of short-term homebased pre- and postoperative exercise on recovery after colorectal cancer surgery (physsurg-c): a randomized clinical trial
topic Randomized Controlled Trials
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820776/
https://www.ncbi.nlm.nih.gov/pubmed/33843798
http://dx.doi.org/10.1097/SLA.0000000000004901
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