Angiogenesis and anti-leukaemia activity of novel indole derivatives as potent colchicine binding site inhibitors

The screened compound DYT-1 from our in-house library was taken as a lead (inhibiting tubulin polymerisation: IC(50)=25.6 µM, anti-angiogenesis in Zebrafish: IC(50)=38.4 µM, anti-proliferation against K562 and Jurkat: IC(50)=6.2 and 7.9 µM, respectively). Further investigation of medicinal chemistry...

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Detalles Bibliográficos
Autores principales: Yao, Yongfang, Huang, Tao, Wang, Yuyang, Wang, Longfei, Feng, Siqi, Cheng, Weyland, Yang, Longhua, Duan, Yongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820799/
https://www.ncbi.nlm.nih.gov/pubmed/35109719
http://dx.doi.org/10.1080/14756366.2022.2032688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820799/
https://www.ncbi.nlm.nih.gov/pubmed/35109719
http://dx.doi.org/10.1080/14756366.2022.2032688

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