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Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2

CCR4-NOT complex-mediated mRNA deadenylation serves critical functions in multiple biological processes, yet how this activity is regulated is not fully understood. Here, we show that osmotic stress induces MAPKAPK-2 (MK2)-mediated phosphorylation of CNOT2. Programmed cell death is greatly enhanced...

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Detalles Bibliográficos
Autores principales:	Suzuki, Toru, Hoshina, Miyuki, Nishijima, Saori, Hoshina, Naosuke, Kikuguchi, Chisato, Tomohiro, Takumi, Fukao, Akira, Fujiwara, Toshinobu, Yamamoto, Tadashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820811/ https://www.ncbi.nlm.nih.gov/pubmed/35129087 http://dx.doi.org/10.1080/15476286.2021.2021676

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