SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly over the world and claimed million lives. The virus evolves constantly, and a swarm of mutants is a now major concern globally. Distinct variants could have independently converged on same mutation, despite being detected in...

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Autores principales: Yang, Wan-Ting, Huang, Wei-Hsuan, Liao, Tsai-Ling, Hsiao, Tzu-Hung, Chuang, Han-Ni, Liu, Po-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820839/
https://www.ncbi.nlm.nih.gov/pubmed/35140483
http://dx.doi.org/10.2147/IDR.S344099
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author Yang, Wan-Ting
Huang, Wei-Hsuan
Liao, Tsai-Ling
Hsiao, Tzu-Hung
Chuang, Han-Ni
Liu, Po-Yu
author_facet Yang, Wan-Ting
Huang, Wei-Hsuan
Liao, Tsai-Ling
Hsiao, Tzu-Hung
Chuang, Han-Ni
Liu, Po-Yu
author_sort Yang, Wan-Ting
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly over the world and claimed million lives. The virus evolves constantly, and a swarm of mutants is a now major concern globally. Distinct variants could have independently converged on same mutation, despite being detected in different geographic regions, which suggested it could confer an evolutionary advantage. E484K has rapidly emerged and has frequently been detected in several SARS-CoV-2 variants of concern. In this study, we review the epidemiology and impact of E484K, its effects on neutralizing effect of several monoclonal antibodies, convalescent plasma, and post-vaccine sera.
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spelling pubmed-88208392022-02-08 SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations Yang, Wan-Ting Huang, Wei-Hsuan Liao, Tsai-Ling Hsiao, Tzu-Hung Chuang, Han-Ni Liu, Po-Yu Infect Drug Resist Review Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread rapidly over the world and claimed million lives. The virus evolves constantly, and a swarm of mutants is a now major concern globally. Distinct variants could have independently converged on same mutation, despite being detected in different geographic regions, which suggested it could confer an evolutionary advantage. E484K has rapidly emerged and has frequently been detected in several SARS-CoV-2 variants of concern. In this study, we review the epidemiology and impact of E484K, its effects on neutralizing effect of several monoclonal antibodies, convalescent plasma, and post-vaccine sera. Dove 2022-02-03 /pmc/articles/PMC8820839/ /pubmed/35140483 http://dx.doi.org/10.2147/IDR.S344099 Text en © 2022 Yang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Yang, Wan-Ting
Huang, Wei-Hsuan
Liao, Tsai-Ling
Hsiao, Tzu-Hung
Chuang, Han-Ni
Liu, Po-Yu
SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations
title SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations
title_full SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations
title_fullStr SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations
title_full_unstemmed SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations
title_short SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations
title_sort sars-cov-2 e484k mutation narrative review: epidemiology, immune escape, clinical implications, and future considerations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820839/
https://www.ncbi.nlm.nih.gov/pubmed/35140483
http://dx.doi.org/10.2147/IDR.S344099
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