Cargando…

Effect of Micronutrients on Thyroid Parameters

Micronutrients are involved in various vital cellular metabolic processes including thyroid hormone metabolism. This study aimed to investigate the correlation between serum levels of micronutrients and their effects on thyroid parameters. The correlation of serum levels of micronutrients and thyroi...

Descripción completa

Detalles Bibliográficos
Autores principales: Krishnamurthy, Hari Krishnan, Reddy, Swarnkumar, Jayaraman, Vasanth, Krishna, Karthik, Song, Qi, Rajasekaran, Karenah E., Wang, Tianhao, Bei, Kang, Rajasekaran, John J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820928/
https://www.ncbi.nlm.nih.gov/pubmed/35140907
http://dx.doi.org/10.1155/2021/1865483
_version_ 1784646311712129024
author Krishnamurthy, Hari Krishnan
Reddy, Swarnkumar
Jayaraman, Vasanth
Krishna, Karthik
Song, Qi
Rajasekaran, Karenah E.
Wang, Tianhao
Bei, Kang
Rajasekaran, John J.
author_facet Krishnamurthy, Hari Krishnan
Reddy, Swarnkumar
Jayaraman, Vasanth
Krishna, Karthik
Song, Qi
Rajasekaran, Karenah E.
Wang, Tianhao
Bei, Kang
Rajasekaran, John J.
author_sort Krishnamurthy, Hari Krishnan
collection PubMed
description Micronutrients are involved in various vital cellular metabolic processes including thyroid hormone metabolism. This study aimed to investigate the correlation between serum levels of micronutrients and their effects on thyroid parameters. The correlation of serum levels of micronutrients and thyroid markers was studied in a group of 387 healthy individuals tested for thyroid markers (T4, T3, FT4, FT3, TSH, anti-TPO, RT3, and anti-Tg) and their micronutrient profile at Vibrant America Clinical Laboratory. The subjects were rationalized into three groups (deficient, normal, or excess levels of micronutrients), and the levels of their thyroid markers were compared. According to our results, deficiency of vitamin B2, B12, B9 and Vit-D25[OH] (p < 0.05) significantly affected thyroid functioning. Other elemental micronutrients such as calcium, copper, choline, iron, and zinc (p < 0.05) have a significant correlation with serum levels of free T3. Amino acids asparagine (r = 0.1765, p < 0.001) and serine (r = 0.1186, p < 0.05) were found to have a strong positive correlation with TSH. Valine, leucine, and arginine (p < 0.05) also exhibited a significant positive correlation with serum levels of T4 and FT4. No other significant correlations were observed with other micronutrients. Our study suggests strong evidence for the association of the levels of micronutrients with thyroid markers with a special note on the effect of serum levels of certain amino acids.
format Online
Article
Text
id pubmed-8820928
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-88209282022-02-08 Effect of Micronutrients on Thyroid Parameters Krishnamurthy, Hari Krishnan Reddy, Swarnkumar Jayaraman, Vasanth Krishna, Karthik Song, Qi Rajasekaran, Karenah E. Wang, Tianhao Bei, Kang Rajasekaran, John J. J Thyroid Res Research Article Micronutrients are involved in various vital cellular metabolic processes including thyroid hormone metabolism. This study aimed to investigate the correlation between serum levels of micronutrients and their effects on thyroid parameters. The correlation of serum levels of micronutrients and thyroid markers was studied in a group of 387 healthy individuals tested for thyroid markers (T4, T3, FT4, FT3, TSH, anti-TPO, RT3, and anti-Tg) and their micronutrient profile at Vibrant America Clinical Laboratory. The subjects were rationalized into three groups (deficient, normal, or excess levels of micronutrients), and the levels of their thyroid markers were compared. According to our results, deficiency of vitamin B2, B12, B9 and Vit-D25[OH] (p < 0.05) significantly affected thyroid functioning. Other elemental micronutrients such as calcium, copper, choline, iron, and zinc (p < 0.05) have a significant correlation with serum levels of free T3. Amino acids asparagine (r = 0.1765, p < 0.001) and serine (r = 0.1186, p < 0.05) were found to have a strong positive correlation with TSH. Valine, leucine, and arginine (p < 0.05) also exhibited a significant positive correlation with serum levels of T4 and FT4. No other significant correlations were observed with other micronutrients. Our study suggests strong evidence for the association of the levels of micronutrients with thyroid markers with a special note on the effect of serum levels of certain amino acids. Hindawi 2021-09-28 /pmc/articles/PMC8820928/ /pubmed/35140907 http://dx.doi.org/10.1155/2021/1865483 Text en Copyright © 2021 Hari Krishnan Krishnamurthy et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Krishnamurthy, Hari Krishnan
Reddy, Swarnkumar
Jayaraman, Vasanth
Krishna, Karthik
Song, Qi
Rajasekaran, Karenah E.
Wang, Tianhao
Bei, Kang
Rajasekaran, John J.
Effect of Micronutrients on Thyroid Parameters
title Effect of Micronutrients on Thyroid Parameters
title_full Effect of Micronutrients on Thyroid Parameters
title_fullStr Effect of Micronutrients on Thyroid Parameters
title_full_unstemmed Effect of Micronutrients on Thyroid Parameters
title_short Effect of Micronutrients on Thyroid Parameters
title_sort effect of micronutrients on thyroid parameters
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820928/
https://www.ncbi.nlm.nih.gov/pubmed/35140907
http://dx.doi.org/10.1155/2021/1865483
work_keys_str_mv AT krishnamurthyharikrishnan effectofmicronutrientsonthyroidparameters
AT reddyswarnkumar effectofmicronutrientsonthyroidparameters
AT jayaramanvasanth effectofmicronutrientsonthyroidparameters
AT krishnakarthik effectofmicronutrientsonthyroidparameters
AT songqi effectofmicronutrientsonthyroidparameters
AT rajasekarankarenahe effectofmicronutrientsonthyroidparameters
AT wangtianhao effectofmicronutrientsonthyroidparameters
AT beikang effectofmicronutrientsonthyroidparameters
AT rajasekaranjohnj effectofmicronutrientsonthyroidparameters