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Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes
Corneal injury is a commonly encountered clinical problem which led to vision loss and impairment that affects millions of people worldwide. Currently, the available treatment in clinical practice is corneal transplantation, which is limited by the accessibility of donors. Corneal tissue engineering...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820938/ https://www.ncbi.nlm.nih.gov/pubmed/35140792 http://dx.doi.org/10.1155/2022/5403995 |
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author | Zhang, Aini Zhang, Wei Backman, Ludvig J. Chen, Jialin |
author_facet | Zhang, Aini Zhang, Wei Backman, Ludvig J. Chen, Jialin |
author_sort | Zhang, Aini |
collection | PubMed |
description | Corneal injury is a commonly encountered clinical problem which led to vision loss and impairment that affects millions of people worldwide. Currently, the available treatment in clinical practice is corneal transplantation, which is limited by the accessibility of donors. Corneal tissue engineering appears to be a promising alternative for corneal repair. However, current experimental strategies of corneal tissue engineering are insufficient due to inadequate differentiation of stem cell into keratocytes and thus cannot be applied in clinical practice. In this review, we aim to clarify the role and effectiveness of both biochemical factors, physical regulation, and the combination of both to induce stem cells to differentiate into keratocytes. We will also propose novel perspectives of differentiation strategy that may help to improve the efficiency of corneal tissue engineering. |
format | Online Article Text |
id | pubmed-8820938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-88209382022-02-08 Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes Zhang, Aini Zhang, Wei Backman, Ludvig J. Chen, Jialin Stem Cells Int Review Article Corneal injury is a commonly encountered clinical problem which led to vision loss and impairment that affects millions of people worldwide. Currently, the available treatment in clinical practice is corneal transplantation, which is limited by the accessibility of donors. Corneal tissue engineering appears to be a promising alternative for corneal repair. However, current experimental strategies of corneal tissue engineering are insufficient due to inadequate differentiation of stem cell into keratocytes and thus cannot be applied in clinical practice. In this review, we aim to clarify the role and effectiveness of both biochemical factors, physical regulation, and the combination of both to induce stem cells to differentiate into keratocytes. We will also propose novel perspectives of differentiation strategy that may help to improve the efficiency of corneal tissue engineering. Hindawi 2022-01-31 /pmc/articles/PMC8820938/ /pubmed/35140792 http://dx.doi.org/10.1155/2022/5403995 Text en Copyright © 2022 Aini Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhang, Aini Zhang, Wei Backman, Ludvig J. Chen, Jialin Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes |
title | Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes |
title_full | Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes |
title_fullStr | Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes |
title_full_unstemmed | Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes |
title_short | Advances in Regulatory Strategies of Differentiating Stem Cells towards Keratocytes |
title_sort | advances in regulatory strategies of differentiating stem cells towards keratocytes |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820938/ https://www.ncbi.nlm.nih.gov/pubmed/35140792 http://dx.doi.org/10.1155/2022/5403995 |
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