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Cardiorespiratory monitoring of red blood cell transfusions in preterm infants

Clinical improvement after red blood cell (RBC) transfusions in preterm infants remains debated. This study aims to investigate the effect of RBC transfusion on the occurrence of desaturations and hypoxia, and other cardiorespiratory outcomes in preterm infants. In this longitudinal observational st...

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Autores principales: Poppe, Jarinda A., van Essen, Tanja, van Weteringen, Willem, Willemsen, Sten P., Reiss, Irwin K. M., Simons, Sinno H. P., de Jonge, Rogier C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821053/
https://www.ncbi.nlm.nih.gov/pubmed/34370081
http://dx.doi.org/10.1007/s00431-021-04218-5
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author Poppe, Jarinda A.
van Essen, Tanja
van Weteringen, Willem
Willemsen, Sten P.
Reiss, Irwin K. M.
Simons, Sinno H. P.
de Jonge, Rogier C. J.
author_facet Poppe, Jarinda A.
van Essen, Tanja
van Weteringen, Willem
Willemsen, Sten P.
Reiss, Irwin K. M.
Simons, Sinno H. P.
de Jonge, Rogier C. J.
author_sort Poppe, Jarinda A.
collection PubMed
description Clinical improvement after red blood cell (RBC) transfusions in preterm infants remains debated. This study aims to investigate the effect of RBC transfusion on the occurrence of desaturations and hypoxia, and other cardiorespiratory outcomes in preterm infants. In this longitudinal observational study, prospectively stored cardiorespiratory parameters of preterm infants who received at least one RBC transfusion between July 2016 and June 2017 were retrospectively analyzed. Sixty infants with 112 RBC transfusions, median GA of 26.7 weeks, were included. The number of desaturations and area < 80% SpO(2) limit, as a measure of the hypoxic burden, were calculated in 24 h before and after RBC transfusion. A mixed effects model was used to account for repeated measurements. Overall, the mean (SE) number of desaturations per hour decreased from 3.28 (0.55) to 2.25 (0.38; p < 0.001), and area < 80% SpO(2) limit decreased from 0.14 (0.04) to 0.08 (0.02) %/s (p = 0.02). These outcomes were stratified for the number of desaturations in 24 h prior to RBC transfusion. The largest effect was observed in the group with the highest mean number of desaturations (≥ 6) prior to RBC transfusion, with a decrease from 7.50 (0.66) to 4.26 (0.38) (p < 0.001) in the number of desaturations and 0.46 (0.13) to 0.20 (0.06) in the area < 80% SpO(2). Perfusion index increased significantly after RBC transfusion (p < 0.001). No other significant effects of RBC transfusion on cardiorespiratory data were observed. Conclusions: RBC transfusions in preterm newborns could help decrease the incidence of desaturations and the area < 80% SpO(2) as a measure of the hypoxic burden. The higher the number of desaturations prior to the RBC transfusion, the larger the effect observed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00431-021-04218-5.
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spelling pubmed-88210532022-02-22 Cardiorespiratory monitoring of red blood cell transfusions in preterm infants Poppe, Jarinda A. van Essen, Tanja van Weteringen, Willem Willemsen, Sten P. Reiss, Irwin K. M. Simons, Sinno H. P. de Jonge, Rogier C. J. Eur J Pediatr Original Article Clinical improvement after red blood cell (RBC) transfusions in preterm infants remains debated. This study aims to investigate the effect of RBC transfusion on the occurrence of desaturations and hypoxia, and other cardiorespiratory outcomes in preterm infants. In this longitudinal observational study, prospectively stored cardiorespiratory parameters of preterm infants who received at least one RBC transfusion between July 2016 and June 2017 were retrospectively analyzed. Sixty infants with 112 RBC transfusions, median GA of 26.7 weeks, were included. The number of desaturations and area < 80% SpO(2) limit, as a measure of the hypoxic burden, were calculated in 24 h before and after RBC transfusion. A mixed effects model was used to account for repeated measurements. Overall, the mean (SE) number of desaturations per hour decreased from 3.28 (0.55) to 2.25 (0.38; p < 0.001), and area < 80% SpO(2) limit decreased from 0.14 (0.04) to 0.08 (0.02) %/s (p = 0.02). These outcomes were stratified for the number of desaturations in 24 h prior to RBC transfusion. The largest effect was observed in the group with the highest mean number of desaturations (≥ 6) prior to RBC transfusion, with a decrease from 7.50 (0.66) to 4.26 (0.38) (p < 0.001) in the number of desaturations and 0.46 (0.13) to 0.20 (0.06) in the area < 80% SpO(2). Perfusion index increased significantly after RBC transfusion (p < 0.001). No other significant effects of RBC transfusion on cardiorespiratory data were observed. Conclusions: RBC transfusions in preterm newborns could help decrease the incidence of desaturations and the area < 80% SpO(2) as a measure of the hypoxic burden. The higher the number of desaturations prior to the RBC transfusion, the larger the effect observed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00431-021-04218-5. Springer Berlin Heidelberg 2021-08-09 2022 /pmc/articles/PMC8821053/ /pubmed/34370081 http://dx.doi.org/10.1007/s00431-021-04218-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Poppe, Jarinda A.
van Essen, Tanja
van Weteringen, Willem
Willemsen, Sten P.
Reiss, Irwin K. M.
Simons, Sinno H. P.
de Jonge, Rogier C. J.
Cardiorespiratory monitoring of red blood cell transfusions in preterm infants
title Cardiorespiratory monitoring of red blood cell transfusions in preterm infants
title_full Cardiorespiratory monitoring of red blood cell transfusions in preterm infants
title_fullStr Cardiorespiratory monitoring of red blood cell transfusions in preterm infants
title_full_unstemmed Cardiorespiratory monitoring of red blood cell transfusions in preterm infants
title_short Cardiorespiratory monitoring of red blood cell transfusions in preterm infants
title_sort cardiorespiratory monitoring of red blood cell transfusions in preterm infants
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821053/
https://www.ncbi.nlm.nih.gov/pubmed/34370081
http://dx.doi.org/10.1007/s00431-021-04218-5
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