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Long Non-coding RNA MALAT1: A Key Player in Liver Diseases

Long non-coding RNAs (lncRNAs) exceed 200 nucleotides in length are considered to be involved in both developmental processes and various diseases. Here, we focus on lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), which was one of the most important lncRNAs in proliferation,...

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Autores principales: Lu, Juan, Guo, Jing, Liu, Jun, Mao, Xiaomin, Xu, Kaijin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821149/
https://www.ncbi.nlm.nih.gov/pubmed/35145971
http://dx.doi.org/10.3389/fmed.2021.734643
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author Lu, Juan
Guo, Jing
Liu, Jun
Mao, Xiaomin
Xu, Kaijin
author_facet Lu, Juan
Guo, Jing
Liu, Jun
Mao, Xiaomin
Xu, Kaijin
author_sort Lu, Juan
collection PubMed
description Long non-coding RNAs (lncRNAs) exceed 200 nucleotides in length are considered to be involved in both developmental processes and various diseases. Here, we focus on lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), which was one of the most important lncRNAs in proliferation, apoptosis, and migration. MALAT1 plays a regulatory role in liver diseases, including hepatic fibrosis, liver regeneration, liver cancer, and fatty liver diseases. In the current review, we summarize the latest literature about the function roles of MALAT1 in liver disorders. Probing the regulatory mechanism and cross talk of MALAT1 with other signaling pathways of pathological processes would improve the prognosis, diagnosis of liver diseases, and offer a promising candidate target for therapeutic interventions.
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spelling pubmed-88211492022-02-09 Long Non-coding RNA MALAT1: A Key Player in Liver Diseases Lu, Juan Guo, Jing Liu, Jun Mao, Xiaomin Xu, Kaijin Front Med (Lausanne) Medicine Long non-coding RNAs (lncRNAs) exceed 200 nucleotides in length are considered to be involved in both developmental processes and various diseases. Here, we focus on lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1), which was one of the most important lncRNAs in proliferation, apoptosis, and migration. MALAT1 plays a regulatory role in liver diseases, including hepatic fibrosis, liver regeneration, liver cancer, and fatty liver diseases. In the current review, we summarize the latest literature about the function roles of MALAT1 in liver disorders. Probing the regulatory mechanism and cross talk of MALAT1 with other signaling pathways of pathological processes would improve the prognosis, diagnosis of liver diseases, and offer a promising candidate target for therapeutic interventions. Frontiers Media S.A. 2022-01-25 /pmc/articles/PMC8821149/ /pubmed/35145971 http://dx.doi.org/10.3389/fmed.2021.734643 Text en Copyright © 2022 Lu, Guo, Liu, Mao and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Lu, Juan
Guo, Jing
Liu, Jun
Mao, Xiaomin
Xu, Kaijin
Long Non-coding RNA MALAT1: A Key Player in Liver Diseases
title Long Non-coding RNA MALAT1: A Key Player in Liver Diseases
title_full Long Non-coding RNA MALAT1: A Key Player in Liver Diseases
title_fullStr Long Non-coding RNA MALAT1: A Key Player in Liver Diseases
title_full_unstemmed Long Non-coding RNA MALAT1: A Key Player in Liver Diseases
title_short Long Non-coding RNA MALAT1: A Key Player in Liver Diseases
title_sort long non-coding rna malat1: a key player in liver diseases
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821149/
https://www.ncbi.nlm.nih.gov/pubmed/35145971
http://dx.doi.org/10.3389/fmed.2021.734643
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