Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers

Natural products have attracted the interest of the scientific community due to their importance and application. Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala. The biological properties such as glycosidase in...

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Autores principales: Mohammadi Ziarani, Ghodsi, Jamasbi, Negar, Mohajer, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821751/
https://www.ncbi.nlm.nih.gov/pubmed/35129687
http://dx.doi.org/10.1007/s13659-022-00324-5
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author Mohammadi Ziarani, Ghodsi
Jamasbi, Negar
Mohajer, Fatemeh
author_facet Mohammadi Ziarani, Ghodsi
Jamasbi, Negar
Mohajer, Fatemeh
author_sort Mohammadi Ziarani, Ghodsi
collection PubMed
description Natural products have attracted the interest of the scientific community due to their importance and application. Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala. The biological properties such as glycosidase inhibitors, anti-virus, and anti-HIV activities, makes it interesting target for synthetical studies. This review reports different approaches and methodologies to the synthesis of alexine, and its stereoisomers as the target compounds in numerous studies. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-88217512022-02-18 Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers Mohammadi Ziarani, Ghodsi Jamasbi, Negar Mohajer, Fatemeh Nat Prod Bioprospect Review Natural products have attracted the interest of the scientific community due to their importance and application. Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala. The biological properties such as glycosidase inhibitors, anti-virus, and anti-HIV activities, makes it interesting target for synthetical studies. This review reports different approaches and methodologies to the synthesis of alexine, and its stereoisomers as the target compounds in numerous studies. GRAPHICAL ABSTRACT: [Image: see text] Springer Singapore 2022-02-07 /pmc/articles/PMC8821751/ /pubmed/35129687 http://dx.doi.org/10.1007/s13659-022-00324-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Mohammadi Ziarani, Ghodsi
Jamasbi, Negar
Mohajer, Fatemeh
Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers
title Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers
title_full Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers
title_fullStr Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers
title_full_unstemmed Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers
title_short Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers
title_sort recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821751/
https://www.ncbi.nlm.nih.gov/pubmed/35129687
http://dx.doi.org/10.1007/s13659-022-00324-5
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