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Magnesium Ions Moderate Calcium-Induced Calcium Release in Cardiac Calcium Release Sites by Binding to Ryanodine Receptor Activation and Inhibition Sites
Ryanodine receptor channels at calcium release sites of cardiac myocytes operate on the principle of calcium-induced calcium release. In vitro experiments revealed competition of Ca(2+) and Mg(2+) in the activation of ryanodine receptors (RyRs) as well as inhibition of RyRs by Mg(2+). The impact of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8821920/ https://www.ncbi.nlm.nih.gov/pubmed/35145426 http://dx.doi.org/10.3389/fphys.2021.805956 |