Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents

A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of...

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Autores principales: Alshabanah, Latifah A., Al-Mutabagani, Laila A., Gomha, Sobhi M., Ahmed, Hoda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822056/
https://www.ncbi.nlm.nih.gov/pubmed/35145952
http://dx.doi.org/10.3389/fchem.2021.762248
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author Alshabanah, Latifah A.
Al-Mutabagani, Laila A.
Gomha, Sobhi M.
Ahmed, Hoda A.
author_facet Alshabanah, Latifah A.
Al-Mutabagani, Laila A.
Gomha, Sobhi M.
Ahmed, Hoda A.
author_sort Alshabanah, Latifah A.
collection PubMed
description A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of compounds displaying a thiazole ring linked to coumarin moiety. Moreover, all the products were evaluated for their anticancer activities against HEPG2-1. The results revealed that three new compounds showed promising anticancer activities.
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spelling pubmed-88220562022-02-09 Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents Alshabanah, Latifah A. Al-Mutabagani, Laila A. Gomha, Sobhi M. Ahmed, Hoda A. Front Chem Chemistry A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of compounds displaying a thiazole ring linked to coumarin moiety. Moreover, all the products were evaluated for their anticancer activities against HEPG2-1. The results revealed that three new compounds showed promising anticancer activities. Frontiers Media S.A. 2022-01-25 /pmc/articles/PMC8822056/ /pubmed/35145952 http://dx.doi.org/10.3389/fchem.2021.762248 Text en Copyright © 2022 Alshabanah, Al-Mutabagani, Gomha and Ahmed. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Alshabanah, Latifah A.
Al-Mutabagani, Laila A.
Gomha, Sobhi M.
Ahmed, Hoda A.
Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents
title Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents
title_full Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents
title_fullStr Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents
title_full_unstemmed Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents
title_short Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents
title_sort three-component synthesis of some new coumarin derivatives as anticancer agents
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822056/
https://www.ncbi.nlm.nih.gov/pubmed/35145952
http://dx.doi.org/10.3389/fchem.2021.762248
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