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Tannic Acid Inhibits Salmonella enterica Serovar Typhimurium Infection by Targeting the Type III Secretion System
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that can cause food poisoning and diarrhea in both humans and animals worldwide. The Salmonella pathogenicity island (SPI) genes encoded type III secretion system (T3SS) is important for S. Typhimurium invasion and repli...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822118/ https://www.ncbi.nlm.nih.gov/pubmed/35145491 http://dx.doi.org/10.3389/fmicb.2021.784926 |
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author | Shu, Jingyan Liu, Hongtao Liu, Yang Chen, Xindi Yu, Yu Lv, Qianghua Wang, Jianfeng Deng, Xuming Guo, Zhimin Qiu, Jiazhang |
author_facet | Shu, Jingyan Liu, Hongtao Liu, Yang Chen, Xindi Yu, Yu Lv, Qianghua Wang, Jianfeng Deng, Xuming Guo, Zhimin Qiu, Jiazhang |
author_sort | Shu, Jingyan |
collection | PubMed |
description | Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that can cause food poisoning and diarrhea in both humans and animals worldwide. The Salmonella pathogenicity island (SPI) genes encoded type III secretion system (T3SS) is important for S. Typhimurium invasion and replication in host cells. Due to the increasing problem of antibiotic resistance, antibiotic treatment for clinical Salmonella infection has gradually been limited. Anti-virulence inhibitors are a promising alternative to antibiotics because they do not easily induce bacterial antibiotic resistance. Here, we systematically evaluated the therapeutic effect of tannic acid (TA) on Salmonella-infected mice and elucidated its anti-infection mechanism. TA treatment improved the survival rate of S. Typhimurium-infected mice and alleviated cecum pathological lesions. In addition, TA inhibited S. Typhimurium invasion to HeLa cells without affecting their growth. Further studies showed that TA could inhibit the expression of sipA and sipB. This inhibition may be implemented by inhibiting the transcription of key regulatory and structural genes of the T3SS. This study provides an alternative anti-virulence strategy for Salmonella infection treatment. |
format | Online Article Text |
id | pubmed-8822118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88221182022-02-09 Tannic Acid Inhibits Salmonella enterica Serovar Typhimurium Infection by Targeting the Type III Secretion System Shu, Jingyan Liu, Hongtao Liu, Yang Chen, Xindi Yu, Yu Lv, Qianghua Wang, Jianfeng Deng, Xuming Guo, Zhimin Qiu, Jiazhang Front Microbiol Microbiology Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that can cause food poisoning and diarrhea in both humans and animals worldwide. The Salmonella pathogenicity island (SPI) genes encoded type III secretion system (T3SS) is important for S. Typhimurium invasion and replication in host cells. Due to the increasing problem of antibiotic resistance, antibiotic treatment for clinical Salmonella infection has gradually been limited. Anti-virulence inhibitors are a promising alternative to antibiotics because they do not easily induce bacterial antibiotic resistance. Here, we systematically evaluated the therapeutic effect of tannic acid (TA) on Salmonella-infected mice and elucidated its anti-infection mechanism. TA treatment improved the survival rate of S. Typhimurium-infected mice and alleviated cecum pathological lesions. In addition, TA inhibited S. Typhimurium invasion to HeLa cells without affecting their growth. Further studies showed that TA could inhibit the expression of sipA and sipB. This inhibition may be implemented by inhibiting the transcription of key regulatory and structural genes of the T3SS. This study provides an alternative anti-virulence strategy for Salmonella infection treatment. Frontiers Media S.A. 2022-01-25 /pmc/articles/PMC8822118/ /pubmed/35145491 http://dx.doi.org/10.3389/fmicb.2021.784926 Text en Copyright © 2022 Shu, Liu, Liu, Chen, Yu, Lv, Wang, Deng, Guo and Qiu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Shu, Jingyan Liu, Hongtao Liu, Yang Chen, Xindi Yu, Yu Lv, Qianghua Wang, Jianfeng Deng, Xuming Guo, Zhimin Qiu, Jiazhang Tannic Acid Inhibits Salmonella enterica Serovar Typhimurium Infection by Targeting the Type III Secretion System |
title | Tannic Acid Inhibits Salmonella enterica Serovar Typhimurium Infection by Targeting the Type III Secretion System |
title_full | Tannic Acid Inhibits Salmonella enterica Serovar Typhimurium Infection by Targeting the Type III Secretion System |
title_fullStr | Tannic Acid Inhibits Salmonella enterica Serovar Typhimurium Infection by Targeting the Type III Secretion System |
title_full_unstemmed | Tannic Acid Inhibits Salmonella enterica Serovar Typhimurium Infection by Targeting the Type III Secretion System |
title_short | Tannic Acid Inhibits Salmonella enterica Serovar Typhimurium Infection by Targeting the Type III Secretion System |
title_sort | tannic acid inhibits salmonella enterica serovar typhimurium infection by targeting the type iii secretion system |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822118/ https://www.ncbi.nlm.nih.gov/pubmed/35145491 http://dx.doi.org/10.3389/fmicb.2021.784926 |
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