A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair

Tissue repair after trauma and infection has always been a difficult problem in regenerative medicine. Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability and water solubility. Especially, the stiffness of hydrogels is a ke...

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Autores principales: Luo, Tianyi, Tan, Bowen, Zhu, Lengjing, Wang, Yating, Liao, Jinfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822157/
https://www.ncbi.nlm.nih.gov/pubmed/35145958
http://dx.doi.org/10.3389/fbioe.2022.817391
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author Luo, Tianyi
Tan, Bowen
Zhu, Lengjing
Wang, Yating
Liao, Jinfeng
author_facet Luo, Tianyi
Tan, Bowen
Zhu, Lengjing
Wang, Yating
Liao, Jinfeng
author_sort Luo, Tianyi
collection PubMed
description Tissue repair after trauma and infection has always been a difficult problem in regenerative medicine. Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability and water solubility. Especially, the stiffness of hydrogels is a key factor, which influence the morphology of mesenchymal stem cells (MSCs) and their differentiation. The researches on this point are meaningful to the field of tissue engineering. Herein, this review focus on the design of hydrogels with different stiffness and their effects on the behavior of MSCs. In addition, the effect of hydrogel stiffness on the phenotype of macrophages is introduced, and then the relationship between the phenotype changes of macrophages on inflammatory response and tissue repair is discussed. Finally, the future application of hydrogels with a certain stiffness in regenerative medicine and tissue engineering has been prospected.
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spelling pubmed-88221572022-02-09 A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair Luo, Tianyi Tan, Bowen Zhu, Lengjing Wang, Yating Liao, Jinfeng Front Bioeng Biotechnol Bioengineering and Biotechnology Tissue repair after trauma and infection has always been a difficult problem in regenerative medicine. Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability and water solubility. Especially, the stiffness of hydrogels is a key factor, which influence the morphology of mesenchymal stem cells (MSCs) and their differentiation. The researches on this point are meaningful to the field of tissue engineering. Herein, this review focus on the design of hydrogels with different stiffness and their effects on the behavior of MSCs. In addition, the effect of hydrogel stiffness on the phenotype of macrophages is introduced, and then the relationship between the phenotype changes of macrophages on inflammatory response and tissue repair is discussed. Finally, the future application of hydrogels with a certain stiffness in regenerative medicine and tissue engineering has been prospected. Frontiers Media S.A. 2022-01-25 /pmc/articles/PMC8822157/ /pubmed/35145958 http://dx.doi.org/10.3389/fbioe.2022.817391 Text en Copyright © 2022 Luo, Tan, Zhu, Wang and Liao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Luo, Tianyi
Tan, Bowen
Zhu, Lengjing
Wang, Yating
Liao, Jinfeng
A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair
title A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair
title_full A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair
title_fullStr A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair
title_full_unstemmed A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair
title_short A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair
title_sort review on the design of hydrogels with different stiffness and their effects on tissue repair
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822157/
https://www.ncbi.nlm.nih.gov/pubmed/35145958
http://dx.doi.org/10.3389/fbioe.2022.817391
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