Pyroptosis and Its Regulation in Diabetic Cardiomyopathy

Diabetic cardiomyopathy (DbCM) is a prevalent disease, characterized by contractile dysfunction and left ventricular hypertrophy. Patients with DbCM have high morbidity and mortality worldwide. Recent studies have identified that pyroptosis, a kind of cell death, could be induced by hyperglycemia in...

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Autores principales: Lu, Yafang, Lu, Yaqiong, Meng, Jun, Wang, Zuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822267/
https://www.ncbi.nlm.nih.gov/pubmed/35145423
http://dx.doi.org/10.3389/fphys.2021.791848
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author Lu, Yafang
Lu, Yaqiong
Meng, Jun
Wang, Zuo
author_facet Lu, Yafang
Lu, Yaqiong
Meng, Jun
Wang, Zuo
author_sort Lu, Yafang
collection PubMed
description Diabetic cardiomyopathy (DbCM) is a prevalent disease, characterized by contractile dysfunction and left ventricular hypertrophy. Patients with DbCM have high morbidity and mortality worldwide. Recent studies have identified that pyroptosis, a kind of cell death, could be induced by hyperglycemia involved in the formation of DbCM. This review summarizes the regulatory mechanisms of pyroptosis in DbCM, including NOD-like receptor3, AIM2 inflammasome, long non-coding RNAs, microRNAs, circular RNA, autophagy, and some drugs.
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spelling pubmed-88222672022-02-09 Pyroptosis and Its Regulation in Diabetic Cardiomyopathy Lu, Yafang Lu, Yaqiong Meng, Jun Wang, Zuo Front Physiol Physiology Diabetic cardiomyopathy (DbCM) is a prevalent disease, characterized by contractile dysfunction and left ventricular hypertrophy. Patients with DbCM have high morbidity and mortality worldwide. Recent studies have identified that pyroptosis, a kind of cell death, could be induced by hyperglycemia involved in the formation of DbCM. This review summarizes the regulatory mechanisms of pyroptosis in DbCM, including NOD-like receptor3, AIM2 inflammasome, long non-coding RNAs, microRNAs, circular RNA, autophagy, and some drugs. Frontiers Media S.A. 2022-01-25 /pmc/articles/PMC8822267/ /pubmed/35145423 http://dx.doi.org/10.3389/fphys.2021.791848 Text en Copyright © 2022 Lu, Lu, Meng and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Lu, Yafang
Lu, Yaqiong
Meng, Jun
Wang, Zuo
Pyroptosis and Its Regulation in Diabetic Cardiomyopathy
title Pyroptosis and Its Regulation in Diabetic Cardiomyopathy
title_full Pyroptosis and Its Regulation in Diabetic Cardiomyopathy
title_fullStr Pyroptosis and Its Regulation in Diabetic Cardiomyopathy
title_full_unstemmed Pyroptosis and Its Regulation in Diabetic Cardiomyopathy
title_short Pyroptosis and Its Regulation in Diabetic Cardiomyopathy
title_sort pyroptosis and its regulation in diabetic cardiomyopathy
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822267/
https://www.ncbi.nlm.nih.gov/pubmed/35145423
http://dx.doi.org/10.3389/fphys.2021.791848
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AT luyaqiong pyroptosisanditsregulationindiabeticcardiomyopathy
AT mengjun pyroptosisanditsregulationindiabeticcardiomyopathy
AT wangzuo pyroptosisanditsregulationindiabeticcardiomyopathy

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