Cargando…

Synthesis and late stage modifications of Cyl derivatives

A peptide Claisen rearrangement is used as key step to generate a tetrapeptide with a C-terminal double unsaturated side chain. Activation and cyclization give direct access to cyclopeptides related to naturally occurring histone deacetylase (HDAC) inhibitors Cyl-1 and Cyl-2. Late stage modification...

Descripción completa

Detalles Bibliográficos
Autores principales:	Servatius, Phil, Kazmaier, Uli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2022
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822456/ https://www.ncbi.nlm.nih.gov/pubmed/35186154 http://dx.doi.org/10.3762/bjoc.18.19

Ejemplares similares

Stereoselective Allylic Alkylations of Amino Ketones and Their Application in the Synthesis of Highly Functionalized Piperidines
por: Prudel, Cynthia, et al.
Publicado: (2020)

A straightforward approach towards combined α-amino and α-hydroxy acids based on Passerini reactions
por: Zahoor, Ameer F, et al.
Publicado: (2011)

Total Synthesis and Biological Evaluation of Modified Ilamycin Derivatives
por: Greve, Jennifer, et al.
Publicado: (2022)

Synthetic studies towards bottromycin
por: Ackermann, Stefanie, et al.
Publicado: (2012)

C‐Functionalized Cationic Diazaoxatriangulenes: Late‐Stage Synthesis and Tuning of Physicochemical Properties
por: Delgado, Irene Hernández, et al.
Publicado: (2018)

New synthesis of a late-stage tetracyclic key intermediate of lumateperone
por: Milen, Mátyás, et al.
Publicado: (2022)

The cyl Genes Reveal the Biosynthetic and Evolutionary Origins of the Group B Streptococcus Hemolytic Lipid, Granadaene
por: Armistead, Blair, et al.
Publicado: (2020)

Red-Brown Pigmentation of Acidipropionibacterium jensenii Is Tied to Haemolytic Activity and cyl-Like Gene Cluster
por: Deptula, Paulina, et al.
Publicado: (2019)

A Straightforward Synthesis of Polyketides via Ester Dienolate Matteson Homologation
por: Andler, Oliver, et al.
Publicado: (2020)

Diversity-oriented synthesis of analogues of the novel macrocyclic peptide FR-225497 through late stage functionalization
por: Mukherjee, Jyotiprasad, et al.
Publicado: (2015)

A Thermal Performance Analysis and Comparison of Fiber Coils with the D-CYL Winding and QAD Winding Methods
por: Li, Xuyou, et al.
Publicado: (2016)

Corrigendum: The cyl Genes Reveal the Biosynthetic and Evolutionary Origins of the Group B Streptococcus Hemolytic Lipid, Granadaene
por: Armistead, Blair, et al.
Publicado: (2020)

A Revised Modular Approach to (–)‐trans‐Δ(8)‐THC and Derivatives Through Late‐Stage Suzuki–Miyaura Cross‐Coupling Reactions
por: Bloemendal, Victor R. L. J., et al.
Publicado: (2019)

Recent Developments on the Synthesis and Bioactivity of Ilamycins/Rufomycins and Cyclomarins, Marine Cyclopeptides That Demonstrate Anti-Malaria and Anti-Tuberculosis Activity
por: Kazmaier, Uli, et al.
Publicado: (2021)

Synthesis and fluorosolvatochromism of 3-arylnaphtho[1,2-b]quinolizinium derivatives
por: Pithan, Phil M, et al.
Publicado: (2016)

Genome-wide Analysis of Chlamydophila pneumoniae Gene Expression at the Late Stage of Infection
por: Miura, Koshiro, et al.
Publicado: (2008)

Synthesis of ergostane-type brassinosteroids with modifications in ring A
por: Zhabinskii, Vladimir N, et al.
Publicado: (2017)

Peptide stapling by late-stage Suzuki–Miyaura cross-coupling
por: Gruß, Hendrik, et al.
Publicado: (2022)

Improved detection of esp, hyl, asa1, gelE, cylA virulence genes among clinical isolates of Enterococci
por: Kiruthiga, Alexander, et al.
Publicado: (2020)

Synthesis of Chiral MOF‐74 Frameworks by Post‐Synthetic Modification by Using an Amino Acid
por: Gheorghe, Andreea, et al.
Publicado: (2020)

Targeting the endoplasmic reticulum-mitochondria interface sensitizes leukemia cells to cytostatics
por: Koczian, Fabian, et al.
Publicado: (2019)

Late-Stage Modification of Medicine: Pd-Catalyzed Direct Synthesis and Biological Evaluation of N-Aryltacrine Derivatives
por: Wan, Lin-Xi, et al.
Publicado: (2021)

Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and Vancomycin
por: Bereczki, Ilona, et al.
Publicado: (2020)

Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use‐Dependent Inhibitors of Voltage‐Gated Sodium Channels
por: Milani, Gualtiero, et al.
Publicado: (2021)

Cascade Metathesis Reactions for the Synthesis of Taxane and Isotaxane Derivatives
por: Ma, Cong, et al.
Publicado: (2016)

Synthesis and Biological Activity of Peptide Derivatives of Iodoquinazolinones/Nitroimidazoles
por: Dahiya, Rajiv, et al.
Publicado: (2008)

Synthesis of acylglycerol derivatives by mechanochemistry
por: Ardila-Fierro, Karen J, et al.
Publicado: (2019)

Synthesis of 5‐Alkyl‐ and 5‐Phenylamino‐Substituted Azothiazole Dyes with Solvatochromic and DNA‐Binding Properties
por: Pithan, Phil M., et al.
Publicado: (2019)

High-resolution structure determination of the CylR2 homodimer using paramagnetic relaxation enhancement and structure-based prediction of molecular alignment
por: Rumpel, Sigrun, et al.
Publicado: (2007)

Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives
por: Logashenko, Evgeniya B, et al.
Publicado: (2011)

Synthesis and in vitro Evaluation of New Benzothiazole Derivatives as Schistosomicidal Agents †
por: Mahran, Mona A., et al.
Publicado: (2007)

Synthesis and Antitumor Evaluation of Novel Hybrids of Phenylsulfonylfuroxan and Estradiol Derivatives
por: Wan, Qi, et al.
Publicado: (2019)

Synthesis, Modification, and Biological Evaluation of a Library of Novel Water‐Soluble Thiopyridone‐Based Organometallic Complexes and Their Unexpected (Biological) Behavior
por: Harringer, Sophia, et al.
Publicado: (2020)

Synthesis and antifungal properties of papulacandin derivatives
por: van der Kaaden, Marjolein, et al.
Publicado: (2012)

Late‐Stage Amination of Drug‐Like Benzoic Acids: Access to Anilines and Drug Conjugates through Directed Iridium‐Catalyzed C−H Activation
por: Weis, Erik, et al.
Publicado: (2021)

Antioxidant Activity of Diphenylpropionamide Derivatives: Synthesis, Biological Evaluation and Computational Analysis
por: Urbani, Paolo, et al.
Publicado: (2008)

Pyrrole‐Protected β‐Aminoalkylzinc Reagents for the Enantioselective Synthesis of Amino‐Derivatives
por: Leroux, Marcel, et al.
Publicado: (2020)

Distribution of cylA, esp, asa1, hyl and gelE virulence genes among clinical isolates of Enterococcus faecium and Entrococcus faecalis
por: Padmasini, Elango, et al.
Publicado: (2014)

The pretubulysin-induced exposure of collagen is caused by endothelial cell retraction that results in an increased adhesion and decreased transmigration of tumor cells
por: Schwenk, Rebecca, et al.
Publicado: (2017)

Synthesis and Antimicrobial Evaluation of 1,4‐Naphthoquinone Derivatives as Potential Antibacterial Agents
por: Ravichandiran, Palanisamy, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_113ee1tv3cl7gev8i0rqu9slir