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Synthesis and late stage modifications of Cyl derivatives

A peptide Claisen rearrangement is used as key step to generate a tetrapeptide with a C-terminal double unsaturated side chain. Activation and cyclization give direct access to cyclopeptides related to naturally occurring histone deacetylase (HDAC) inhibitors Cyl-1 and Cyl-2. Late stage modification...

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Detalles Bibliográficos
Autores principales:	Servatius, Phil, Kazmaier, Uli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2022
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822456/ https://www.ncbi.nlm.nih.gov/pubmed/35186154 http://dx.doi.org/10.3762/bjoc.18.19

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