Asymmetric organocatalytic Michael addition of cyclopentane-1,2-dione to alkylidene oxindole

An asymmetric Michael reaction between cyclopentane-1,2-dione and alkylidene oxindole was studied in the presence of a multifunctional squaramide catalyst. Michael adducts were obtained in high enantioselectivities and in moderate diastereoselectivities.

Detalles Bibliográficos
Autores principales: Silm, Estelle, Järving, Ivar, Kanger, Tõnis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2022
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822468/
https://www.ncbi.nlm.nih.gov/pubmed/35186153
http://dx.doi.org/10.3762/bjoc.18.18
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author Silm, Estelle
Järving, Ivar
Kanger, Tõnis
author_facet Silm, Estelle
Järving, Ivar
Kanger, Tõnis
author_sort Silm, Estelle
collection PubMed
description An asymmetric Michael reaction between cyclopentane-1,2-dione and alkylidene oxindole was studied in the presence of a multifunctional squaramide catalyst. Michael adducts were obtained in high enantioselectivities and in moderate diastereoselectivities.
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spelling pubmed-88224682022-02-17 Asymmetric organocatalytic Michael addition of cyclopentane-1,2-dione to alkylidene oxindole Silm, Estelle Järving, Ivar Kanger, Tõnis Beilstein J Org Chem Full Research Paper An asymmetric Michael reaction between cyclopentane-1,2-dione and alkylidene oxindole was studied in the presence of a multifunctional squaramide catalyst. Michael adducts were obtained in high enantioselectivities and in moderate diastereoselectivities. Beilstein-Institut 2022-02-03 /pmc/articles/PMC8822468/ /pubmed/35186153 http://dx.doi.org/10.3762/bjoc.18.18 Text en Copyright © 2022, Silm et al. https://creativecommons.org/licenses/by/4.0/This is an open access article licensed under the terms of the Beilstein-Institut Open Access License Agreement (https://www.beilstein-journals.org/bjoc/terms/terms), which is identical to the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ). The reuse of material under this license requires that the author(s), source and license are credited. Third-party material in this article could be subject to other licenses (typically indicated in the credit line), and in this case, users are required to obtain permission from the license holder to reuse the material.
spellingShingle Full Research Paper
Silm, Estelle
Järving, Ivar
Kanger, Tõnis
Asymmetric organocatalytic Michael addition of cyclopentane-1,2-dione to alkylidene oxindole
title Asymmetric organocatalytic Michael addition of cyclopentane-1,2-dione to alkylidene oxindole
title_full Asymmetric organocatalytic Michael addition of cyclopentane-1,2-dione to alkylidene oxindole
title_fullStr Asymmetric organocatalytic Michael addition of cyclopentane-1,2-dione to alkylidene oxindole
title_full_unstemmed Asymmetric organocatalytic Michael addition of cyclopentane-1,2-dione to alkylidene oxindole
title_short Asymmetric organocatalytic Michael addition of cyclopentane-1,2-dione to alkylidene oxindole
title_sort asymmetric organocatalytic michael addition of cyclopentane-1,2-dione to alkylidene oxindole
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822468/
https://www.ncbi.nlm.nih.gov/pubmed/35186153
http://dx.doi.org/10.3762/bjoc.18.18
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AT kangertonis asymmetricorganocatalyticmichaeladditionofcyclopentane12dionetoalkylideneoxindole

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