Enantioselective Flow Synthesis of Rolipram Enabled by a Telescoped Asymmetric Conjugate Addition–Oxidative Aldehyde Esterification Sequence Using in Situ-Generated Persulfuric Acid as Oxidant

[Image: see text] A novel approach is reported for the enantioselective flow synthesis of rolipram comprising a telescoped asymmetric conjugate addition–oxidative aldehyde esterification sequence followed by trichlorosilane-mediated nitro group reduction and concomitant lactamization. The telescoped...

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Detalles Bibliográficos
Autores principales: Nagy, Bence S., Llanes, Patricia, Pericas, Miquel A., Kappe, C. Oliver, Ötvös, Sándor B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822492/
https://www.ncbi.nlm.nih.gov/pubmed/35050638
http://dx.doi.org/10.1021/acs.orglett.1c04300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822492/
https://www.ncbi.nlm.nih.gov/pubmed/35050638
http://dx.doi.org/10.1021/acs.orglett.1c04300

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