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Gut bacterial metabolite Urolithin A inhibits myocardial fibrosis through activation of Nrf2 pathway in vitro and in vivo

BACKGROUND: Myocardial fibrosis after myocardial infarction (MI) is one of the leading causes of cardiovascular diseases. Cardiac fibroblasts (CFs) are activated and promoted by MI to undergo myofibroblast transformation (CMT). Urolithin A (UA) is an active and effective gut metabolite derived from...

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Detalles Bibliográficos
Autores principales:	Chen, Pengfei, Pei, Junyu, Wang, Xiaopu, Tai, Shi, Tang, Liang, Hu, Xinqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822684/ https://www.ncbi.nlm.nih.gov/pubmed/35135471 http://dx.doi.org/10.1186/s10020-022-00444-1

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