Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives

BACKGROUND: Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma proliferation. Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting CLIC1 activity, but its low potency hampers its translation in clinical settings. METHODS: We synthesized a small library...

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Detalles Bibliográficos
Autores principales: Barbieri, Federica, Bosio, Alessia Graziana, Pattarozzi, Alessandra, Tonelli, Michele, Bajetto, Adriana, Verduci, Ivan, Cianci, Francesca, Cannavale, Gaetano, Palloni, Luca M. G., Francesconi, Valeria, Thellung, Stefano, Fiaschi, Pietro, Mazzetti, Samanta, Schenone, Silvia, Balboni, Beatrice, Girotto, Stefania, Malatesta, Paolo, Daga, Antonio, Zona, Gianluigi, Mazzanti, Michele, Florio, Tullio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822754/
https://www.ncbi.nlm.nih.gov/pubmed/35135603
http://dx.doi.org/10.1186/s13046-021-02213-0

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