Cardiac hypertrophy and insulin therapy in a pre-term newborn: is there a relationship?

BACKGROUND: Hypertrophic cardiomyopathy (HCM) in newborns is a rare condition with heterogeneous etiologies. While the relationship between hyperinsulinism and cardiac hypertrophy (CH) is known, hyperinsulinism has not been reported as cause of HCM. CASE PRESENTATION: We report the case of cardiac h...

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Autores principales: Salvatori, Guglielmo, Brindisi, Giulia, Colantonio, Mario, Zicari, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822805/
https://www.ncbi.nlm.nih.gov/pubmed/35135591
http://dx.doi.org/10.1186/s13052-022-01216-7
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author Salvatori, Guglielmo
Brindisi, Giulia
Colantonio, Mario
Zicari, Anna Maria
author_facet Salvatori, Guglielmo
Brindisi, Giulia
Colantonio, Mario
Zicari, Anna Maria
author_sort Salvatori, Guglielmo
collection PubMed
description BACKGROUND: Hypertrophic cardiomyopathy (HCM) in newborns is a rare condition with heterogeneous etiologies. While the relationship between hyperinsulinism and cardiac hypertrophy (CH) is known, hyperinsulinism has not been reported as cause of HCM. CASE PRESENTATION: We report the case of cardiac hypertrophy (CH) in an Extremely Low Birth Weight (ELBW) infant; this patient underwent insulin therapy after the onset of persistent hyperglycemia due to parenteral nutrition (PN), supporting the hypothesis of a role of iatrogenic hyperinsulinemia in the development of HCM. CONCLUSIONS: The present case underlines the importance of a close cardiological follow-up in infants undergoing insulin infusion for an alteration in the glucose metabolism.
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spelling pubmed-88228052022-02-08 Cardiac hypertrophy and insulin therapy in a pre-term newborn: is there a relationship? Salvatori, Guglielmo Brindisi, Giulia Colantonio, Mario Zicari, Anna Maria Ital J Pediatr Case Report BACKGROUND: Hypertrophic cardiomyopathy (HCM) in newborns is a rare condition with heterogeneous etiologies. While the relationship between hyperinsulinism and cardiac hypertrophy (CH) is known, hyperinsulinism has not been reported as cause of HCM. CASE PRESENTATION: We report the case of cardiac hypertrophy (CH) in an Extremely Low Birth Weight (ELBW) infant; this patient underwent insulin therapy after the onset of persistent hyperglycemia due to parenteral nutrition (PN), supporting the hypothesis of a role of iatrogenic hyperinsulinemia in the development of HCM. CONCLUSIONS: The present case underlines the importance of a close cardiological follow-up in infants undergoing insulin infusion for an alteration in the glucose metabolism. BioMed Central 2022-02-08 /pmc/articles/PMC8822805/ /pubmed/35135591 http://dx.doi.org/10.1186/s13052-022-01216-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Salvatori, Guglielmo
Brindisi, Giulia
Colantonio, Mario
Zicari, Anna Maria
Cardiac hypertrophy and insulin therapy in a pre-term newborn: is there a relationship?
title Cardiac hypertrophy and insulin therapy in a pre-term newborn: is there a relationship?
title_full Cardiac hypertrophy and insulin therapy in a pre-term newborn: is there a relationship?
title_fullStr Cardiac hypertrophy and insulin therapy in a pre-term newborn: is there a relationship?
title_full_unstemmed Cardiac hypertrophy and insulin therapy in a pre-term newborn: is there a relationship?
title_short Cardiac hypertrophy and insulin therapy in a pre-term newborn: is there a relationship?
title_sort cardiac hypertrophy and insulin therapy in a pre-term newborn: is there a relationship?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822805/
https://www.ncbi.nlm.nih.gov/pubmed/35135591
http://dx.doi.org/10.1186/s13052-022-01216-7
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