The effect of estrogen on brown adipose tissue activity in male rats

OBJECTIVE: Centrally administered estrogen can increase sympathetic nerve activity to brown adipose tissue, resulting in thermogenesis. The central thermogenic effects of estrogen have not been investigated in males. Therefore, this study sought to investigate the effects of peripherally and central...

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Autores principales: Sievers, W., Kettle, C., Green, R. A., Van Schaik, L., Hale, M. W., Irving, H. R., Whelan, D. R., Rathner, J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822813/
https://www.ncbi.nlm.nih.gov/pubmed/35135593
http://dx.doi.org/10.1186/s13104-022-05910-x
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author Sievers, W.
Kettle, C.
Green, R. A.
Van Schaik, L.
Hale, M. W.
Irving, H. R.
Whelan, D. R.
Rathner, J. A.
author_facet Sievers, W.
Kettle, C.
Green, R. A.
Van Schaik, L.
Hale, M. W.
Irving, H. R.
Whelan, D. R.
Rathner, J. A.
author_sort Sievers, W.
collection PubMed
description OBJECTIVE: Centrally administered estrogen can increase sympathetic nerve activity to brown adipose tissue, resulting in thermogenesis. The central thermogenic effects of estrogen have not been investigated in males. Therefore, this study sought to investigate the effects of peripherally and centrally administered estrogen on thermogenesis, heart rate and mean arterial pressure in male rats. Thermogenesis was assessed by monitoring brown adipose tissue temperature. RESULTS: Peripherally administered estrogen elicited no significant effect on brown adipose tissue temperature, heart rate or mean arterial pressure. Centrally administered estrogen elicited a coincident increase in both brown adipose tissue and core temperature. Centrally administered estrogen also resulted in a decrease in mean arterial pressure but had no effect on heart rate. With the present data it is not possible to elucidate whether changes in temperature were the result of thermogenic or thermoregulatory mechanisms. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-022-05910-x.
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spelling pubmed-88228132022-02-08 The effect of estrogen on brown adipose tissue activity in male rats Sievers, W. Kettle, C. Green, R. A. Van Schaik, L. Hale, M. W. Irving, H. R. Whelan, D. R. Rathner, J. A. BMC Res Notes Research Note OBJECTIVE: Centrally administered estrogen can increase sympathetic nerve activity to brown adipose tissue, resulting in thermogenesis. The central thermogenic effects of estrogen have not been investigated in males. Therefore, this study sought to investigate the effects of peripherally and centrally administered estrogen on thermogenesis, heart rate and mean arterial pressure in male rats. Thermogenesis was assessed by monitoring brown adipose tissue temperature. RESULTS: Peripherally administered estrogen elicited no significant effect on brown adipose tissue temperature, heart rate or mean arterial pressure. Centrally administered estrogen elicited a coincident increase in both brown adipose tissue and core temperature. Centrally administered estrogen also resulted in a decrease in mean arterial pressure but had no effect on heart rate. With the present data it is not possible to elucidate whether changes in temperature were the result of thermogenic or thermoregulatory mechanisms. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13104-022-05910-x. BioMed Central 2022-02-08 /pmc/articles/PMC8822813/ /pubmed/35135593 http://dx.doi.org/10.1186/s13104-022-05910-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Sievers, W.
Kettle, C.
Green, R. A.
Van Schaik, L.
Hale, M. W.
Irving, H. R.
Whelan, D. R.
Rathner, J. A.
The effect of estrogen on brown adipose tissue activity in male rats
title The effect of estrogen on brown adipose tissue activity in male rats
title_full The effect of estrogen on brown adipose tissue activity in male rats
title_fullStr The effect of estrogen on brown adipose tissue activity in male rats
title_full_unstemmed The effect of estrogen on brown adipose tissue activity in male rats
title_short The effect of estrogen on brown adipose tissue activity in male rats
title_sort effect of estrogen on brown adipose tissue activity in male rats
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822813/
https://www.ncbi.nlm.nih.gov/pubmed/35135593
http://dx.doi.org/10.1186/s13104-022-05910-x
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