4564 Nilotinib alters microRNAs that regulate specific autophagy and ubiquitination genes in the cerebrospinal fluid of Parkinson’s patients

OBJECTIVES/GOALS: Our preclinical data demonstrate that the principal effects of nilotinib, a multi-tyrosine kinase inhibitor, in models of neurodegeneration is clearance of misfolded proteins via autophagy. Here we aimed to evaluate the effects of nilotinib on microRNAs in the cerebrospinal fluid o...

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Detalles Bibliográficos
Autores principales: Fowler, Alan, Torres-Yhagi, Yasar, Pagan, Fernando, Hebron, Michaeline, Willmarth, Barbara, Arellano, Joy, Howard, Helen, Matar, Sara, Chiu, Timothy, Ahn, Jaeil, Moussa, Charbel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Mechanistic Basic to Clinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822937/
http://dx.doi.org/10.1017/cts.2020.308

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