4528 Sirtuin 3 activation as a potential renoprotective therapy in a mouse model of Alport syndrome

OBJECTIVES/GOALS: Sirtuin 3 (Sirt3), a mitochondrial NAD(+)-dependent deacetylase, is decreased in diverse models of kidney disease, and Sirt3 activation prevents disease progression in many of those models. We are investigating if pharmacological activation of Sirt3 ameliorates kidney disease in a...

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Detalles Bibliográficos
Autores principales: Jones, Bryce, Myakala, Komuraiah, Wang, Xiaoxin, Libby, Andrew, Takahashi, Shogo, Bhasin, Kanchan, Ranjit, Suman, Rosenberg, Avi, Levi, Moshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Basic Science/Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822961/
http://dx.doi.org/10.1017/cts.2020.91

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