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4392 Comparative Analysis of Vascular Hemodynamics in a Young Biracial Cohort
OBJECTIVES/GOALS: We investigated hemodynamic measures in young black and white adults below the age of 50 years to identify mechanisms that may predispose blacks to more CVE. METHODS/STUDY POPULATION: We recruited 276 young blacks and white adults in Jackson, MS (mean age: 33 ± 9 years; 70% women;...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823026/ http://dx.doi.org/10.1017/cts.2020.116 |
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author | Bell, Preston Fox, Ervin Musani, Solomon Mitchell, Gary |
author_facet | Bell, Preston Fox, Ervin Musani, Solomon Mitchell, Gary |
author_sort | Bell, Preston |
collection | PubMed |
description | OBJECTIVES/GOALS: We investigated hemodynamic measures in young black and white adults below the age of 50 years to identify mechanisms that may predispose blacks to more CVE. METHODS/STUDY POPULATION: We recruited 276 young blacks and white adults in Jackson, MS (mean age: 33 ± 9 years; 70% women; 57% Black;). Participants had clinical and vascular tonometry parameters obtained. Vascular measures included carotid femoral pulse wave velocity, central and peripheral pulse pressure (CPP and PPP), characteristic impedance (Z(c)), augmentation index, and forward pressure wave. Race-specific characteristic means and proportions were tested using Student’s T- or Chi-square tests. After further sex stratification, significant variation in characteristics among sex within race were tested using nested ANOVA. RESULTS/ANTICIPATED RESULTS: Characteristics of the study group stratified by race were found to be similar. Vascular measures stratified by race revealed blacks to have significantly higher Z(c) (p = 0.03) and PPP (p = 0.03) than whites. DISCUSSION/SIGNIFICANCE OF IMPACT: In this study of vascular hemodynamics in young black and white participants we found differences in Z(c) and PPP. Findings suggest that differing relations between proximal aortic diameter and wall stiffness may contribute to the racial disparity in CVE in adults. This finding could offer an explanation to the beneficial effects of treatment modalities that target aortic stiffness in blacks. |
format | Online Article Text |
id | pubmed-8823026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88230262022-02-18 4392 Comparative Analysis of Vascular Hemodynamics in a Young Biracial Cohort Bell, Preston Fox, Ervin Musani, Solomon Mitchell, Gary J Clin Transl Sci Clinical Epidemiology/Clinical Trial OBJECTIVES/GOALS: We investigated hemodynamic measures in young black and white adults below the age of 50 years to identify mechanisms that may predispose blacks to more CVE. METHODS/STUDY POPULATION: We recruited 276 young blacks and white adults in Jackson, MS (mean age: 33 ± 9 years; 70% women; 57% Black;). Participants had clinical and vascular tonometry parameters obtained. Vascular measures included carotid femoral pulse wave velocity, central and peripheral pulse pressure (CPP and PPP), characteristic impedance (Z(c)), augmentation index, and forward pressure wave. Race-specific characteristic means and proportions were tested using Student’s T- or Chi-square tests. After further sex stratification, significant variation in characteristics among sex within race were tested using nested ANOVA. RESULTS/ANTICIPATED RESULTS: Characteristics of the study group stratified by race were found to be similar. Vascular measures stratified by race revealed blacks to have significantly higher Z(c) (p = 0.03) and PPP (p = 0.03) than whites. DISCUSSION/SIGNIFICANCE OF IMPACT: In this study of vascular hemodynamics in young black and white participants we found differences in Z(c) and PPP. Findings suggest that differing relations between proximal aortic diameter and wall stiffness may contribute to the racial disparity in CVE in adults. This finding could offer an explanation to the beneficial effects of treatment modalities that target aortic stiffness in blacks. Cambridge University Press 2020-07-29 /pmc/articles/PMC8823026/ http://dx.doi.org/10.1017/cts.2020.116 Text en © The Association for Clinical and Translational Science 2020 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Epidemiology/Clinical Trial Bell, Preston Fox, Ervin Musani, Solomon Mitchell, Gary 4392 Comparative Analysis of Vascular Hemodynamics in a Young Biracial Cohort |
title | 4392 Comparative Analysis of Vascular Hemodynamics in a Young Biracial Cohort |
title_full | 4392 Comparative Analysis of Vascular Hemodynamics in a Young Biracial Cohort |
title_fullStr | 4392 Comparative Analysis of Vascular Hemodynamics in a Young Biracial Cohort |
title_full_unstemmed | 4392 Comparative Analysis of Vascular Hemodynamics in a Young Biracial Cohort |
title_short | 4392 Comparative Analysis of Vascular Hemodynamics in a Young Biracial Cohort |
title_sort | 4392 comparative analysis of vascular hemodynamics in a young biracial cohort |
topic | Clinical Epidemiology/Clinical Trial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823026/ http://dx.doi.org/10.1017/cts.2020.116 |
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