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4322 Structure-guided design of the TIL1383I T cell receptor

OBJECTIVES/GOALS: Our goal is to employ a structure-guided design approach to engineering a safer and more effective variant of the TIL1383I T cell receptor (TCR) currently under study in clinical trials for malignant melanoma METHODS/STUDY POPULATION: Using our unpublished structure of TIL1383I we...

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Detalles Bibliográficos
Autores principales:	Alonso, Jesus, Singh, Nishant, Devlin, Jason, Davancaze, Lauren, Baker, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2020
Materias:	Basic Science/Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823069/ http://dx.doi.org/10.1017/cts.2020.93

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