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4159 Prostate cancer multiparametric MRI comparison study of 3T versus 7T in terms of lesion detection and image quality

OBJECTIVES/GOALS: The goal of this study was to perform a comparative, multi-reader, retrospective clinical evaluation of prostate multiparametric MRI (mpMRI) at 3 Tesla (3T) vs. 7 Tesla (7T) primarily in terms of prostate cancer localization. Subjective measures of image quality and artifacts were...

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Autores principales: Leng, Ethan, Spilseth, Benjamin, Chauhan, Anil, Gill, Joseph, Rosa, Ana, Koopmeiners, Joseph, Warlick, Christopher, Metzger, Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823231/
http://dx.doi.org/10.1017/cts.2020.141
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author Leng, Ethan
Spilseth, Benjamin
Chauhan, Anil
Gill, Joseph
Rosa, Ana
Koopmeiners, Joseph
Warlick, Christopher
Metzger, Gregory
author_facet Leng, Ethan
Spilseth, Benjamin
Chauhan, Anil
Gill, Joseph
Rosa, Ana
Koopmeiners, Joseph
Warlick, Christopher
Metzger, Gregory
author_sort Leng, Ethan
collection PubMed
description OBJECTIVES/GOALS: The goal of this study was to perform a comparative, multi-reader, retrospective clinical evaluation of prostate multiparametric MRI (mpMRI) at 3 Tesla (3T) vs. 7 Tesla (7T) primarily in terms of prostate cancer localization. Subjective measures of image quality and artifacts were also evaluated. METHODS/STUDY POPULATION: Nineteen subjects were imaged at 3T and 7T between March 2016 and October 2018 under IRB-approved protocols. Four radiologists retrospectively and independently reviewed the data, and completed a two-part assessment for each dataset. First, readers assessed likelihood of cancer using Prostate Imaging Reporting & Data System (PI-RADS) guidelines. Accuracy of cancer detection was compared to findings from prostate biopsy. The numbers of correctly or incorrectly classified sextants were summed across all four readers, then used to summarize detection performance. Second, readers assigned a score on a five-point Likert scale to multiple image quality characteristics for the 3T and 7T datasets. RESULTS/ANTICIPATED RESULTS: Sensitivity and specificity of 3T and 7T datasets for sextant-wise cancer detection were compared by paired two-tailed t-tests. Readers identified more sextants harboring cancer with the 3T datasets while false-positive rates were similar, resulting in significantly higher sensitivity at 3T with no significant differences in specificity. Likert scores for image quality characteristics for 3T and 7T datasets were compared by applying paired two-tailed t-tests to mean scores of the four radiologists for each dataset. Readers generally preferred the 3T datasets, in particular for staging and assessment of extraprostatic extension as well as overall quality of the contrast-enhanced data. DISCUSSION/SIGNIFICANCE OF IMPACT: Readers agreed 7T prostate mpMRI produced images with more anatomic detail, though with equivocal clinical relevance and more pronounced artifacts. Reader unfamiliarity with 7T images is a major extenuating factor. Forthcoming technological developments are anticipated to improve upon the results.
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spelling pubmed-88232312022-02-18 4159 Prostate cancer multiparametric MRI comparison study of 3T versus 7T in terms of lesion detection and image quality Leng, Ethan Spilseth, Benjamin Chauhan, Anil Gill, Joseph Rosa, Ana Koopmeiners, Joseph Warlick, Christopher Metzger, Gregory J Clin Transl Sci Clinical Epidemiology/Clinical Trial OBJECTIVES/GOALS: The goal of this study was to perform a comparative, multi-reader, retrospective clinical evaluation of prostate multiparametric MRI (mpMRI) at 3 Tesla (3T) vs. 7 Tesla (7T) primarily in terms of prostate cancer localization. Subjective measures of image quality and artifacts were also evaluated. METHODS/STUDY POPULATION: Nineteen subjects were imaged at 3T and 7T between March 2016 and October 2018 under IRB-approved protocols. Four radiologists retrospectively and independently reviewed the data, and completed a two-part assessment for each dataset. First, readers assessed likelihood of cancer using Prostate Imaging Reporting & Data System (PI-RADS) guidelines. Accuracy of cancer detection was compared to findings from prostate biopsy. The numbers of correctly or incorrectly classified sextants were summed across all four readers, then used to summarize detection performance. Second, readers assigned a score on a five-point Likert scale to multiple image quality characteristics for the 3T and 7T datasets. RESULTS/ANTICIPATED RESULTS: Sensitivity and specificity of 3T and 7T datasets for sextant-wise cancer detection were compared by paired two-tailed t-tests. Readers identified more sextants harboring cancer with the 3T datasets while false-positive rates were similar, resulting in significantly higher sensitivity at 3T with no significant differences in specificity. Likert scores for image quality characteristics for 3T and 7T datasets were compared by applying paired two-tailed t-tests to mean scores of the four radiologists for each dataset. Readers generally preferred the 3T datasets, in particular for staging and assessment of extraprostatic extension as well as overall quality of the contrast-enhanced data. DISCUSSION/SIGNIFICANCE OF IMPACT: Readers agreed 7T prostate mpMRI produced images with more anatomic detail, though with equivocal clinical relevance and more pronounced artifacts. Reader unfamiliarity with 7T images is a major extenuating factor. Forthcoming technological developments are anticipated to improve upon the results. Cambridge University Press 2020-07-29 /pmc/articles/PMC8823231/ http://dx.doi.org/10.1017/cts.2020.141 Text en © The Association for Clinical and Translational Science 2020 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Epidemiology/Clinical Trial
Leng, Ethan
Spilseth, Benjamin
Chauhan, Anil
Gill, Joseph
Rosa, Ana
Koopmeiners, Joseph
Warlick, Christopher
Metzger, Gregory
4159 Prostate cancer multiparametric MRI comparison study of 3T versus 7T in terms of lesion detection and image quality
title 4159 Prostate cancer multiparametric MRI comparison study of 3T versus 7T in terms of lesion detection and image quality
title_full 4159 Prostate cancer multiparametric MRI comparison study of 3T versus 7T in terms of lesion detection and image quality
title_fullStr 4159 Prostate cancer multiparametric MRI comparison study of 3T versus 7T in terms of lesion detection and image quality
title_full_unstemmed 4159 Prostate cancer multiparametric MRI comparison study of 3T versus 7T in terms of lesion detection and image quality
title_short 4159 Prostate cancer multiparametric MRI comparison study of 3T versus 7T in terms of lesion detection and image quality
title_sort 4159 prostate cancer multiparametric mri comparison study of 3t versus 7t in terms of lesion detection and image quality
topic Clinical Epidemiology/Clinical Trial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823231/
http://dx.doi.org/10.1017/cts.2020.141
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