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Inhibition of integrin αvβ6 sparks T-cell antitumor response and enhances immune checkpoint blockade therapy in colorectal cancer

BACKGROUND: Integrin αvβ6 is a heterodimeric cell surface protein whose cellular expression is determined by the availability of the integrin β6 subunit (ITGB6). It is expressed at very low levels in most organs during tissue homeostasis but shows highly upregulated expression during the process of...

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Detalles Bibliográficos
Autores principales:	Busenhart, Philipp, Montalban-Arques, Ana, Katkeviciute, Egle, Morsy, Yasser, Van Passen, Chiara, Hering, Larissa, Atrott, Kirstin, Lang, Silvia, Garzon, Jesus Francisco Glaus, Naschberger, Elisabeth, Hartmann, Arndt, Rogler, Gerhard, Stürzl, Michael, Spalinger, Marianne Rebecca, Scharl, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823245/ https://www.ncbi.nlm.nih.gov/pubmed/35131862 http://dx.doi.org/10.1136/jitc-2021-003465

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