Rationally targeted anti-VISTA antibody that blockades the C-C’ loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner

BACKGROUND: Despite significant progress in cancer immunotherapy in recent years, resistance to existing immune checkpoint therapies (ICT) is common. V-domain Ig suppressor of T cell activation (VISTA), a predominantly myeloid immune checkpoint regulator, represents a promising therapeutic target du...

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Detalles Bibliográficos
Autores principales: Thakkar, Dipti, Paliwal, Shalini, Dharmadhikari, Bhushan, Guan, Siyu, Liu, Lillian, Kar, Shreya, Tulsian, Nikhil K, Gruber, Joshua J, DiMascio, Leah, Paszkiewicz, Konrad H, Ingram, Piers J, D Boyd-Kirkup, Jerome
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823246/
https://www.ncbi.nlm.nih.gov/pubmed/35131861
http://dx.doi.org/10.1136/jitc-2021-003382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823246/
https://www.ncbi.nlm.nih.gov/pubmed/35131861
http://dx.doi.org/10.1136/jitc-2021-003382

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