4512 Allopregnanolone Dose Finding for Status Epilepticus Treatment by Pharmacokinetic-Pharmacodynamic Modeling using Quantitative EEG in Dogs

OBJECTIVES/GOALS: Allopregnanolone (ALLO), a modulator of GABA(A) receptors, may be useful as a treatment for human and canine benzodiazepine-refractory status epilepticus (SE). Our objective was to develop a phamacokinetic-pharmacodynamic (PKPD) model relating ALLO plasma concentrations to electroe...

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Detalles Bibliográficos
Autores principales: Patterson, Edward “Ned”, Vuu, Irene, Zolkowska, Dorota, Wu, Chun-Yi, Leppik, Ilo, Worrell, Greg, Kremen, Vaclav, Cloyd, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Basic Science/Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823320/
http://dx.doi.org/10.1017/cts.2020.51

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