Cargando…
The level of transforming growth factor-β as a possible predictor of cyclophosphamide response in children with steroid-resistant nephrotic syndrome
BACKGROUND: Steroid-resistant nephrotic syndrome (SRNS) is a burden in the country due to the progressive severity of chronic kidney disease (CKD). Calcineurin inhibitors (CNIs) or monoclonal antibodies are currently recommended for the treatment of this disease. In developing countries, steroid and...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
China Medical University
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823489/ https://www.ncbi.nlm.nih.gov/pubmed/35223413 http://dx.doi.org/10.37796/2211-8039.1205 |
_version_ | 1784646812699721728 |
---|---|
author | Widiasta, Ahmedz Wahyudi, Kurnia Sribudiani, Yunia Rachmadi, Dedi |
author_facet | Widiasta, Ahmedz Wahyudi, Kurnia Sribudiani, Yunia Rachmadi, Dedi |
author_sort | Widiasta, Ahmedz |
collection | PubMed |
description | BACKGROUND: Steroid-resistant nephrotic syndrome (SRNS) is a burden in the country due to the progressive severity of chronic kidney disease (CKD). Calcineurin inhibitors (CNIs) or monoclonal antibodies are currently recommended for the treatment of this disease. In developing countries, steroid and cyclophosphamide (CPA) are available drugs used during the treatment. This study aims to provide a non-invasive modality that can be used to predict the response of SRNS children to CPA therapy. Subsequently, the proteinuria duration was shortened to reduce the risk of glomerular damage. The present study aims to determine whether there is a correlation between baseline serum TGFB and proteinuria in SRNS children six months after receiving CPA treatment. The author hypothesized that there would be a negative correlation between those variables. METHOD: A prospective-cohort-study was conducted at Hasan Sadikin General Hospital Bandung, Indonesia. A total of 88 SRNS children, aged 1 to 18 were accessed for serum TGF-β level before receiving CPA therapy for six months, and clinical signs were observed. Furthermore, after six months of CPA treatment, the subjects were divided into CPA responder and non-responder based on the presence of proteinuria, then the data were analyzed using multiple logistic regression to adjust age and gender. RESULTS: There was a statistically significant relationship between TGF-β and the risk of non-response to CPA therapy, after accounting for age, gender, baseline GFR, baseline ureum, and baseline urinary protein, the adjusted-OR was 1.051 (95% CI 1.007, 1.097, p = 0.022). CONCLUSION: The high level of serum TGF-β obtained prior to CPA administration are reliable data for estimating adverse results on CPA therapy. Based on these results, a high baseline TGF-β level correlates with the poor response of CPA therapy. |
format | Online Article Text |
id | pubmed-8823489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | China Medical University |
record_format | MEDLINE/PubMed |
spelling | pubmed-88234892022-02-25 The level of transforming growth factor-β as a possible predictor of cyclophosphamide response in children with steroid-resistant nephrotic syndrome Widiasta, Ahmedz Wahyudi, Kurnia Sribudiani, Yunia Rachmadi, Dedi Biomedicine (Taipei) Original Article BACKGROUND: Steroid-resistant nephrotic syndrome (SRNS) is a burden in the country due to the progressive severity of chronic kidney disease (CKD). Calcineurin inhibitors (CNIs) or monoclonal antibodies are currently recommended for the treatment of this disease. In developing countries, steroid and cyclophosphamide (CPA) are available drugs used during the treatment. This study aims to provide a non-invasive modality that can be used to predict the response of SRNS children to CPA therapy. Subsequently, the proteinuria duration was shortened to reduce the risk of glomerular damage. The present study aims to determine whether there is a correlation between baseline serum TGFB and proteinuria in SRNS children six months after receiving CPA treatment. The author hypothesized that there would be a negative correlation between those variables. METHOD: A prospective-cohort-study was conducted at Hasan Sadikin General Hospital Bandung, Indonesia. A total of 88 SRNS children, aged 1 to 18 were accessed for serum TGF-β level before receiving CPA therapy for six months, and clinical signs were observed. Furthermore, after six months of CPA treatment, the subjects were divided into CPA responder and non-responder based on the presence of proteinuria, then the data were analyzed using multiple logistic regression to adjust age and gender. RESULTS: There was a statistically significant relationship between TGF-β and the risk of non-response to CPA therapy, after accounting for age, gender, baseline GFR, baseline ureum, and baseline urinary protein, the adjusted-OR was 1.051 (95% CI 1.007, 1.097, p = 0.022). CONCLUSION: The high level of serum TGF-β obtained prior to CPA administration are reliable data for estimating adverse results on CPA therapy. Based on these results, a high baseline TGF-β level correlates with the poor response of CPA therapy. China Medical University 2021-09-01 /pmc/articles/PMC8823489/ /pubmed/35223413 http://dx.doi.org/10.37796/2211-8039.1205 Text en © the Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Original Article Widiasta, Ahmedz Wahyudi, Kurnia Sribudiani, Yunia Rachmadi, Dedi The level of transforming growth factor-β as a possible predictor of cyclophosphamide response in children with steroid-resistant nephrotic syndrome |
title | The level of transforming growth factor-β as a possible predictor of cyclophosphamide response in children with steroid-resistant nephrotic syndrome |
title_full | The level of transforming growth factor-β as a possible predictor of cyclophosphamide response in children with steroid-resistant nephrotic syndrome |
title_fullStr | The level of transforming growth factor-β as a possible predictor of cyclophosphamide response in children with steroid-resistant nephrotic syndrome |
title_full_unstemmed | The level of transforming growth factor-β as a possible predictor of cyclophosphamide response in children with steroid-resistant nephrotic syndrome |
title_short | The level of transforming growth factor-β as a possible predictor of cyclophosphamide response in children with steroid-resistant nephrotic syndrome |
title_sort | level of transforming growth factor-β as a possible predictor of cyclophosphamide response in children with steroid-resistant nephrotic syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823489/ https://www.ncbi.nlm.nih.gov/pubmed/35223413 http://dx.doi.org/10.37796/2211-8039.1205 |
work_keys_str_mv | AT widiastaahmedz theleveloftransforminggrowthfactorbasapossiblepredictorofcyclophosphamideresponseinchildrenwithsteroidresistantnephroticsyndrome AT wahyudikurnia theleveloftransforminggrowthfactorbasapossiblepredictorofcyclophosphamideresponseinchildrenwithsteroidresistantnephroticsyndrome AT sribudianiyunia theleveloftransforminggrowthfactorbasapossiblepredictorofcyclophosphamideresponseinchildrenwithsteroidresistantnephroticsyndrome AT rachmadidedi theleveloftransforminggrowthfactorbasapossiblepredictorofcyclophosphamideresponseinchildrenwithsteroidresistantnephroticsyndrome AT widiastaahmedz leveloftransforminggrowthfactorbasapossiblepredictorofcyclophosphamideresponseinchildrenwithsteroidresistantnephroticsyndrome AT wahyudikurnia leveloftransforminggrowthfactorbasapossiblepredictorofcyclophosphamideresponseinchildrenwithsteroidresistantnephroticsyndrome AT sribudianiyunia leveloftransforminggrowthfactorbasapossiblepredictorofcyclophosphamideresponseinchildrenwithsteroidresistantnephroticsyndrome AT rachmadidedi leveloftransforminggrowthfactorbasapossiblepredictorofcyclophosphamideresponseinchildrenwithsteroidresistantnephroticsyndrome |