4026 Dissecting the role of microenvironment heterogeneity on metastatic tumor cell phenotype at an engineered metastatic niche

OBJECTIVES/GOALS: Breast cancer metastases are stochastic and difficult to detect. Therapy is often ineffective due to phenotypic changes of tumor cells at these sites. We engineered a synthetic metastatic niche to study the role of phenotypic transitions in the microenvironment on tumor cell phenot...

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Detalles Bibliográficos
Autores principales: Orbach, Sophia, Brooks, Michael D., Bushnell, Grace G., Wicha, Max S., Jeruss, Jacqueline S., Shea, Lonnie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Basic Science/Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823657/
http://dx.doi.org/10.1017/cts.2020.62

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