Antisense Oligonucleotide-Induced Amyloid Precursor Protein Splicing Modulation as a Therapeutic Approach for Dutch-Type Cerebral Amyloid Angiopathy

Dutch-type cerebral amyloid angiopathy (D-CAA) is a monogenic form of cerebral amyloid angiopathy and is inherited in an autosomal dominant manner. The disease is caused by a point mutation in exon 17 of the amyloid precursor protein (APP) gene that leads to an amino acid substitution at codon 693....

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Detalles Bibliográficos
Autores principales: Daoutsali, Elena, Hailu, Tsinatkeab T., Buijsen, Ronald A.M., Pepers, Barry A., van der Graaf, Linda M., Verbeek, Marcel M., Curtis, Daniel, de Vlaam, Thomas, van Roon-Mom, Willeke M.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823675/
https://www.ncbi.nlm.nih.gov/pubmed/34061681
http://dx.doi.org/10.1089/nat.2021.0005

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