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The Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β

Transforming growth factor-β (TGF-β) plays a critical role in regulating cell growth and differentiation. Epithelial to mesenchymal transition (EMT) induced by TGF-β promotes cancer cell migration, invasion, and proliferation. Pirfenidone (5-methyl-1-phenyl-2(1 H)-pyridone, PFD), an approved drug fo...

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Detalles Bibliográficos
Autores principales:	Wang, Gang, Zhou, Xiaowan, Guo, Zengli, Huang, Nan, Li, Juan, Lv, Yanfang, Han, Lulu, Zheng, Wei, Xu, Dandan, Chai, Dafei, Li, Huizhong, Li, Liantao, Zheng, Junnian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824226/ https://www.ncbi.nlm.nih.gov/pubmed/35130111 http://dx.doi.org/10.1080/15384047.2022.2035629

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