LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex

The Mre11-Rad50-Nbs1 protein complex is one of the first responders to DNA double-strand breaks. Studies have shown that the catalytic activities of the evolutionarily conserved Mre11-Rad50 (MR) core complex depend on an ATP-dependent global conformational change that takes the macromolecule from an...

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Detalles Bibliográficos
Autores principales: Canny, Marella D, Latham, Michael P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824468/
https://www.ncbi.nlm.nih.gov/pubmed/35084331
http://dx.doi.org/10.7554/eLife.69579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824468/
https://www.ncbi.nlm.nih.gov/pubmed/35084331
http://dx.doi.org/10.7554/eLife.69579

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