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Structural basis for cytoplasmic dynein-1 regulation by Lis1

The lissencephaly 1 gene, LIS1, is mutated in patients with the neurodevelopmental disease lissencephaly. The Lis1 protein is conserved from fungi to mammals and is a key regulator of cytoplasmic dynein-1, the major minus-end-directed microtubule motor in many eukaryotes. Lis1 is the only dynein reg...

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Detalles Bibliográficos
Autores principales:	Gillies, John P, Reimer, Janice M, Karasmanis, Eva P, Lahiri, Indrajit, Htet, Zaw Min, Leschziner, Andres E, Reck-Peterson, Samara L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824474/ https://www.ncbi.nlm.nih.gov/pubmed/34994688 http://dx.doi.org/10.7554/eLife.71229

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