Protein-lipid interaction at low pH induces oligomerization of the MakA cytotoxin from Vibrio cholerae

The α-pore-forming toxins (α-PFTs) from pathogenic bacteria damage host cell membranes by pore formation. We demonstrate a remarkable, hitherto unknown mechanism by an α-PFT protein from Vibrio cholerae. As part of the MakA/B/E tripartite toxin, MakA is involved in membrane pore formation similar to...

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Detalles Bibliográficos
Autores principales: Nadeem, Aftab, Berg, Alexandra, Pace, Hudson, Alam, Athar, Toh, Eric, Ådén, Jörgen, Zlatkov, Nikola, Myint, Si Lhyam, Persson, Karina, Gröbner, Gerhard, Sjöstedt, Anders, Bally, Marta, Barandun, Jonas, Uhlin, Bernt Eric, Wai, Sun Nyunt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824476/
https://www.ncbi.nlm.nih.gov/pubmed/35131030
http://dx.doi.org/10.7554/eLife.73439

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