Cargando…
Distinct cerebellar regions for body motion discrimination
Visual processing of human movements is critical for adaptive social behavior. Cerebellar activations have been observed during biological motion discrimination in prior neuroimaging studies, and cerebellar lesions may be detrimental for this task. However, whether the cerebellum plays a causal role...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824544/ https://www.ncbi.nlm.nih.gov/pubmed/31820788 http://dx.doi.org/10.1093/scan/nsz088 |
_version_ | 1784647036263464960 |
---|---|
author | Ferrari, Chiara Ciricugno, Andrea Battelli, Lorella Grossman, Emily D Cattaneo, Zaira |
author_facet | Ferrari, Chiara Ciricugno, Andrea Battelli, Lorella Grossman, Emily D Cattaneo, Zaira |
author_sort | Ferrari, Chiara |
collection | PubMed |
description | Visual processing of human movements is critical for adaptive social behavior. Cerebellar activations have been observed during biological motion discrimination in prior neuroimaging studies, and cerebellar lesions may be detrimental for this task. However, whether the cerebellum plays a causal role in biological motion discrimination has never been tested. Here, we addressed this issue in three different experiments by interfering with the posterior cerebellar lobe using transcranial magnetic stimulation (TMS) during a biological discrimination task. In Experiments 1 and 2, we found that TMS delivered at onset of the visual stimuli over the vermis (vermal lobule VI), but not over the left cerebellar hemisphere (left lobule VI/Crus I), interfered with participants’ ability to distinguish biological from scrambled motion compared to stimulation of a control site (vertex). Interestingly, when stimulation was delivered at a later time point (300 ms after stimulus onset), participants performed worse when TMS was delivered over the left cerebellar hemisphere compared to the vermis and the vertex (Experiment 3). Our data show that the posterior cerebellum is causally involved in biological motion discrimination and suggest that different sectors of the posterior cerebellar lobe may contribute to the task at different time points. |
format | Online Article Text |
id | pubmed-8824544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-88245442022-02-09 Distinct cerebellar regions for body motion discrimination Ferrari, Chiara Ciricugno, Andrea Battelli, Lorella Grossman, Emily D Cattaneo, Zaira Soc Cogn Affect Neurosci Original Manuscript Visual processing of human movements is critical for adaptive social behavior. Cerebellar activations have been observed during biological motion discrimination in prior neuroimaging studies, and cerebellar lesions may be detrimental for this task. However, whether the cerebellum plays a causal role in biological motion discrimination has never been tested. Here, we addressed this issue in three different experiments by interfering with the posterior cerebellar lobe using transcranial magnetic stimulation (TMS) during a biological discrimination task. In Experiments 1 and 2, we found that TMS delivered at onset of the visual stimuli over the vermis (vermal lobule VI), but not over the left cerebellar hemisphere (left lobule VI/Crus I), interfered with participants’ ability to distinguish biological from scrambled motion compared to stimulation of a control site (vertex). Interestingly, when stimulation was delivered at a later time point (300 ms after stimulus onset), participants performed worse when TMS was delivered over the left cerebellar hemisphere compared to the vermis and the vertex (Experiment 3). Our data show that the posterior cerebellum is causally involved in biological motion discrimination and suggest that different sectors of the posterior cerebellar lobe may contribute to the task at different time points. Oxford University Press 2019-12-10 /pmc/articles/PMC8824544/ /pubmed/31820788 http://dx.doi.org/10.1093/scan/nsz088 Text en © The Author(s) 2019. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Original Manuscript Ferrari, Chiara Ciricugno, Andrea Battelli, Lorella Grossman, Emily D Cattaneo, Zaira Distinct cerebellar regions for body motion discrimination |
title | Distinct cerebellar regions for body motion discrimination |
title_full | Distinct cerebellar regions for body motion discrimination |
title_fullStr | Distinct cerebellar regions for body motion discrimination |
title_full_unstemmed | Distinct cerebellar regions for body motion discrimination |
title_short | Distinct cerebellar regions for body motion discrimination |
title_sort | distinct cerebellar regions for body motion discrimination |
topic | Original Manuscript |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824544/ https://www.ncbi.nlm.nih.gov/pubmed/31820788 http://dx.doi.org/10.1093/scan/nsz088 |
work_keys_str_mv | AT ferrarichiara distinctcerebellarregionsforbodymotiondiscrimination AT ciricugnoandrea distinctcerebellarregionsforbodymotiondiscrimination AT battellilorella distinctcerebellarregionsforbodymotiondiscrimination AT grossmanemilyd distinctcerebellarregionsforbodymotiondiscrimination AT cattaneozaira distinctcerebellarregionsforbodymotiondiscrimination |